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S. Putano, F. Montaldi, C. Corsi; Retinal Sensitivity Evaluation of Diabetic Subjects Treated With Sildenafil for Endothelial Disfunction. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4669.
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To evaluate Sildenafil effects on retinal sensitivity and fixation, in patients affected by diabetes mellitus I
We selected 72 patients (71 eyes) affected by diabetes mellitus I; all subjects underwent to a complete ophthalmologic visit cohmprensive of Visual Acuity measurement, evaluation of anterior and posterior segment, microperimetry by MP-1, and fixation stability evaluation. Subject with cataract and corneal diseases were excluded. Group 1 (36 patients - 33 eyes) were treated with placebo; to group 2 (36 patients - 33 eyes) were administered Sildenafil 200 mg/die, two groups results after three months therapy, were compared and statistically analyzed with T Student test.
Group1 mean retinal sensitivity measured by microperimeter MP1 was: at T0 = 16,65dB; T1=14,82dB ; Group 2 mean retinal sensitivity was T0=16,86dB ; T1=17,63 dB. T-Student Test resulted p=0,0001
Our results demonstrate the improving of retinal sensitivity and fixation stability after 3 months of Sildenafil treatment. Patients treated with placebo showed a reduction of retinal sensitivity according to diabetic endothelial damage.We can affirm that sildenafil induces intrinsic changes in the choroidal vasculature, with a positive impact on pericentral retinal sensitivity. This effect may be of clinical utility.
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