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L. H. Lima, V. C. Greenstein, T. Burke, W. Cella, L. Yannuzzi, S. H. Tsang; Progressive Constriction of the Hyperautofluorescent Ring Marks Outer Segment Deterioration in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4790.
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© ARVO (1962-2015); The Authors (2016-present)
To determine whether there is constriction of the hyperautofluorescent ring visible on fundus autofluorescence (FAF) in patients with retinitis pigmentosa (RP) over time.
Fifteen eyes of 15 RP genotyped patients with a hyperautofluorescent ring, aged 17-68 years, were studied. Visual acuities ranged from 20/20 to 20/60. FAF imaging was performed on all patients using a confocal scanning laser ophthalmoscope (OCT-SLO Spectralis, HRA 2; Heidelberg Engineering). Spectral domain optical coherence tomography (SD-OCT) was obtained on 7 of the patients (7 eyes) using the Cirrus Spectral Domain OCT (Zeiss Meditec Inc,). The constriction of the hyperautofluorescent ring was evaluated by comparing measurements of the external boundaries of the ring on FAF along the vertical and horizontal axes at baseline and at follow-up examinations. All FAF images were overlaid using MatLab software program. The % change in the extent of the inner/outer segment (IS/OS) junction length observed on SD-OCT foveal line scans at baseline and at follow-up examinations was calculated.
Patients were followed for a minimum of 12 months and a maximum of 18 months. For all 15 eyes there was a decrease in diameter in the hyperautofluorecent ring for both vertical and horizontal axes. The mean decrease in the horizontal axis compared to baseline was 1.7% (range: 0.3% - 4.6%) at 12 months and 2.7% (range: 2.4% - 2.8%) at 18 months. The mean decrease in the vertical axis was 2.3% (range: 1.2% - 5.4%) and 3.0% (range: 2.1% - 4.4%) at 12 months and 18 months, respectively. SD-OCT obtained on 7 eyes showed a decrease in the IS/OS junction length. The mean decrease in IS/OS junction length was 2.3% (range: 1.3% - 4.6%) at 12 months and 3.8% (range: 2.5% - 5.9%) at 18 months.
In RP patients, there is constriction of the diameter of the hyperautofluorescent ring observed on FAF over time and a decrease in IS/OS junction length as the disease progresses.
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