April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Progressive Constriction of the Hyperautofluorescent Ring Marks Outer Segment Deterioration in Retinitis Pigmentosa
L. H. Lima; V. C. Greenstein; T. Burke; W. Cella; L. Yannuzzi; S. H. Tsang
Author Affiliations & Notes
  • L. H. Lima
    Ophthalmology, Federal University of Sao Paulo-UNIFESP, Sao Paulo, Brazil
    Ophthalmology, The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York
  • V. C. Greenstein
    Ophthalmology, Columbia University, New York, New York
  • T. Burke
    Ophthalmology, Columbia University, New York, New York
  • W. Cella
    Ophthalmology, Columbia University, New York, New York
  • L. Yannuzzi
    Ophthalmology, The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York
  • S. H. Tsang
    Ophthalmology, Columbia University, New York, New York
    Pathology & Cell Biology, Bernard & Shirlee Brown Glaucoma Laboratory, Edward S. Harkness Eye Institute, Columbia University, New York, New York
  • Footnotes
    Commercial Relationships  L.H. Lima, None; V.C. Greenstein, None; T. Burke, None; W. Cella, None; L. Yannuzzi, None; S.H. Tsang, None.
  • Footnotes
    Support  NIH Grants EY02115, EY09076, EY018213, FFB and RPB
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4790. doi:
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      L. H. Lima, V. C. Greenstein, T. Burke, W. Cella, L. Yannuzzi, S. H. Tsang; Progressive Constriction of the Hyperautofluorescent Ring Marks Outer Segment Deterioration in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4790.

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Abstract

Purpose: : To determine whether there is constriction of the hyperautofluorescent ring visible on fundus autofluorescence (FAF) in patients with retinitis pigmentosa (RP) over time.

Methods: : Fifteen eyes of 15 RP genotyped patients with a hyperautofluorescent ring, aged 17-68 years, were studied. Visual acuities ranged from 20/20 to 20/60. FAF imaging was performed on all patients using a confocal scanning laser ophthalmoscope (OCT-SLO Spectralis, HRA 2; Heidelberg Engineering). Spectral domain optical coherence tomography (SD-OCT) was obtained on 7 of the patients (7 eyes) using the Cirrus Spectral Domain OCT (Zeiss Meditec Inc,). The constriction of the hyperautofluorescent ring was evaluated by comparing measurements of the external boundaries of the ring on FAF along the vertical and horizontal axes at baseline and at follow-up examinations. All FAF images were overlaid using MatLab software program. The % change in the extent of the inner/outer segment (IS/OS) junction length observed on SD-OCT foveal line scans at baseline and at follow-up examinations was calculated.

Results: : Patients were followed for a minimum of 12 months and a maximum of 18 months. For all 15 eyes there was a decrease in diameter in the hyperautofluorecent ring for both vertical and horizontal axes. The mean decrease in the horizontal axis compared to baseline was 1.7% (range: 0.3% - 4.6%) at 12 months and 2.7% (range: 2.4% - 2.8%) at 18 months. The mean decrease in the vertical axis was 2.3% (range: 1.2% - 5.4%) and 3.0% (range: 2.1% - 4.4%) at 12 months and 18 months, respectively. SD-OCT obtained on 7 eyes showed a decrease in the IS/OS junction length. The mean decrease in IS/OS junction length was 2.3% (range: 1.3% - 4.6%) at 12 months and 3.8% (range: 2.5% - 5.9%) at 18 months.

Conclusions: : In RP patients, there is constriction of the diameter of the hyperautofluorescent ring observed on FAF over time and a decrease in IS/OS junction length as the disease progresses.

Keywords: retina • retinal degenerations: hereditary • imaging/image analysis: clinical 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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