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S. Lee, S. Usui, A.-B. Zafar, Y. Jo, B. Oveson, L. Lu, P. A. Campochiaro; Long Term Effect of Oral N-Acetylcysteine on Slowing Photoreceptor Cell Death in a Mouse Model of Retinitis Pigmentosa (RP). Invest. Ophthalmol. Vis. Sci. 2010;51(13):4791.
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In a previous study, we demonstrated that the orally active antioxidant, N-acetylcysteine (NAC) slows cone death and preserves cone function in the early stages (P50) of degeneration in rd 10+/+ mice. We have now investigated the long term effects of NAC (up to P180) and explored whether pharmacologic and genetic therapies (transgenic expression of SOD2 and catalase in photoreceptors) provide additive benefits.
The orally active antioxidant, NAC, significantly preserves cone cell function for up to 6 months in a model of RP. Combining pharmacologic (NAC) and gene-based (increased expression of catalase and SOD2 in photoreceptors) approaches may help to maximize benefits in RP.
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