April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Long Term Effect of Oral N-Acetylcysteine on Slowing Photoreceptor Cell Death in a Mouse Model of Retinitis Pigmentosa (RP)
S. Lee; S. Usui; A.-B. Zafar; Y. Jo; B. Oveson; L. Lu; P. A. Campochiaro
Author Affiliations & Notes
  • S. Lee
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • S. Usui
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • A.-B. Zafar
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • Y. Jo
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • B. Oveson
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • L. Lu
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • P. A. Campochiaro
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  S. Lee, None; S. Usui, None; A.-B. Zafar, None; Y. Jo, None; B. Oveson, None; L. Lu, None; P.A. Campochiaro, None.
  • Footnotes
    Support  NEI grant EY05951
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4791. doi:
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      S. Lee, S. Usui, A.-B. Zafar, Y. Jo, B. Oveson, L. Lu, P. A. Campochiaro; Long Term Effect of Oral N-Acetylcysteine on Slowing Photoreceptor Cell Death in a Mouse Model of Retinitis Pigmentosa (RP). Invest. Ophthalmol. Vis. Sci. 2010;51(13):4791.

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Abstract

Purpose: : In a previous study, we demonstrated that the orally active antioxidant, N-acetylcysteine (NAC) slows cone death and preserves cone function in the early stages (P50) of degeneration in rd 10+/+ mice. We have now investigated the long term effects of NAC (up to P180) and explored whether pharmacologic and genetic therapies (transgenic expression of SOD2 and catalase in photoreceptors) provide additive benefits.

Methods: : Rd10+/+

Results: : Rd10+/+

Conclusions: : The orally active antioxidant, NAC, significantly preserves cone cell function for up to 6 months in a model of RP. Combining pharmacologic (NAC) and gene-based (increased expression of catalase and SOD2 in photoreceptors) approaches may help to maximize benefits in RP.

Keywords: oxidation/oxidative or free radical damage • antioxidants 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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