Uveitis Ocular Damage Could Be Associated With Increased Frequency of CD8+CD57+CD103+CD108+ Cells

Abstract

Purpose: : To evaluate the frequency of CD103+, CD108+, CCR9+ and CLA+ cells on CD8+CD57+ cells in uveitis patients.

Methods: : CD103, CD108, CCR9 and CLA frequency on CD8+CD57+ cells was assessed by flow cytometry on peripheral blood mononuclear cells from uveitis patients. Data were analyzed with Mann Withney U Test, and differences were considered statistically significant with p<0.05

Results: : CD103 expression was 2.4 times increased on CD8+CD57+ T cells subsets compared to CD8+CD57- T cells subset (p=0.0465). We observed a higher frequency of CD108 expression on CD8+CD57+ T cells than on CD8+CD57- T cells subsets (p=0.0076). We did not observe any significant statistical difference in the frequency of CCR9+ cells on CD8+CD57+ (16.3%±6%) or CD8+CD57- (15.9%±7%) and CLA+ cells on CD8+CD57+ (3.2%±1%) or CD8+CD57- (4%±2%)

Conclusions: : CD103 is an integrin expressed on lymphocyte cells in process of homing to effector tissues. On the other hand CD108 has a critical function in the effector phase of the inflammatory immune response (cell proliferation, chemotaxis and cytokine release). CD8+CD57+ bearing CD103 and CD108 could be involved in the pathogenesis of uveitis.

Keywords: autoimmune disease • uvea • immunomodulation/immunoregulation