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A. Robles-Contreras, S. Groman-Lupa, M. Pedroza-Seres, V. Bautista De Lucio, Y. Garfias, M. C. Jimenez- Martinez; Uveitis Ocular Damage Could Be Associated With Increased Frequency of CD8+CD57+CD103+CD108+ Cells. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4848.
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To evaluate the frequency of CD103+, CD108+, CCR9+ and CLA+ cells on CD8+CD57+ cells in uveitis patients.
CD103, CD108, CCR9 and CLA frequency on CD8+CD57+ cells was assessed by flow cytometry on peripheral blood mononuclear cells from uveitis patients. Data were analyzed with Mann Withney U Test, and differences were considered statistically significant with p<0.05
CD103 expression was 2.4 times increased on CD8+CD57+ T cells subsets compared to CD8+CD57- T cells subset (p=0.0465). We observed a higher frequency of CD108 expression on CD8+CD57+ T cells than on CD8+CD57- T cells subsets (p=0.0076). We did not observe any significant statistical difference in the frequency of CCR9+ cells on CD8+CD57+ (16.3%±6%) or CD8+CD57- (15.9%±7%) and CLA+ cells on CD8+CD57+ (3.2%±1%) or CD8+CD57- (4%±2%)
CD103 is an integrin expressed on lymphocyte cells in process of homing to effector tissues. On the other hand CD108 has a critical function in the effector phase of the inflammatory immune response (cell proliferation, chemotaxis and cytokine release). CD8+CD57+ bearing CD103 and CD108 could be involved in the pathogenesis of uveitis.
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