April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Interleukin-17 in Various Ocular Surface Inflammatory Diseases
Author Affiliations & Notes
  • E.-S. Han
    Ophthalmology, Seoul National Univerisity College of Medicine, Seoul, Republic of Korea
    Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • M. Kang
    Ophthalmology, Seoul National Univerisity College of Medicine, Seoul, Republic of Korea
    Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • M. Kim
    Ophthalmology, Seoul National Univerisity College of Medicine, Seoul, Republic of Korea
    Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • W. Wee
    Ophthalmology, Seoul National Univerisity College of Medicine, Seoul, Republic of Korea
    Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • J. Lee
    Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
    Department of ophthalmology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Footnotes
    Commercial Relationships  E.-S. Han, None; M. Kang, None; M. Kim, None; W. Wee, None; J. Lee, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4870. doi:
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      E.-S. Han, M. Kang, M. Kim, W. Wee, J. Lee; Interleukin-17 in Various Ocular Surface Inflammatory Diseases. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4870.

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Abstract

Purpose: : To evaluate Interleukin (IL)-17 of the tears in various ocular surface inflammatory diseases and to investigate clinical correlation of IL-17 with various ocular surface inflammatory diseases.

Methods: : We measured concentrations of IL-17 in tears of normal subject (n=6) and patients with meibomianitis (n=30), dry eye syndrome (n=15), Sjogren syndrome (n=21), Stevens-Johnson syndrome (SJS, n=5) and graft-versus-host disease (GVHD, n=7).The patients who took the oral steroid, topical steroid or cyclosporine were excluded. Tears were taken by soaking with Schirmer strips and concentrations of IL-17 were measured with anti-human IL-17 antibody (Human IL-17 DuoSet, R&D System, Inc., USA) by ELISA. We classified the clinical scores by the surface area of fluorescein staining on cornea and conjunctiva and investigate the correlation of IL-17 with clinical scores.

Results: : Average concentrations of IL-17 in tears of patients with meibomianitis, dry eye syndrome, Sjogren syndrome, and GVHD were significantly higher than that of normal subject (p < 0.05). The concentration of IL-17 was highest in GVHD, followed by Sjogren syndrome, meibomianitis and dry eye syndrome in order. Comparing that of dry eye syndrome with others, those of Sjogren syndrome and GVHD were significantly higher (p <0.05). The correlation of the clinical scores with level of IL-17 in tears showed statistical significance (p <0.05).

Conclusions: : GVHD, Sjogren syndrome, meibomianitis and dry eye syndrome is likely to be associated with IL-17 secreting T cell involved inflammation.

Keywords: cytokines/chemokines • inflammation 
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