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J. Lee, W. Lee, K. Lim, H. Cho; Longitudinal Retinal Nerve Fiber Layer Change and Visual Field Change in Normal Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4892.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate a longitudinal retinal nerve fiber layer (RNFL) thickness change and visual field change in patients with normal tension glaucoma (NTG).
50 eyes of 50 NTG patients and 50 eyes of 50 normal control subjects were enrolled. RNFL thickness was measured by Optical coherence tomograph (OCT) and visual field test was performed by Humphrey visual field analyzer at the baseline and 23.3 months later. Changes in RNFL thickness at each clock hour area and visual field sensitivities were analyzed. The rates of changes in RNFL thickness were also calculated.
Significant differences in RNFL thickness were found between NTG patients and normal control subjects at 5, 6, 7 and 12 o’clock position at the baseline (p<0.001). Over the follow up period, a RNFL thickness change was not significant for normal control subjects, but significant for NTG patients at 4, 5, 6, 7, 10, 11 and 12 o’clock position (p<0.001). Visual field parameters did not change significantly in both normal control subjects and NTG patients. The reduction rate of RNFL thickness was 0.32µm/month with NTG patients, while it was 0.11µm/month for normal control group, displaying 2.9 times faster reduction rate for NTG patients.
The NTG group showed a greater reduction in RNFL thickness in the upper and lower directions over time, but visual field parameters did not change significantly. It suggests that the progression of glaucoma can be detected faster by OCT than visual field test.
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