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A. Schulze, J. Lamparter, N. Pfeiffer, E. M. Hoffmann; Comparison of Optic Disc Topographic Measurements Using Fourier-Domain Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoscopy in Glaucoma Patients and Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4895.
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© ARVO (1962-2015); The Authors (2016-present)
Imaging systems are useful tools for diagnosis and progression analysis of glaucoma. The next generation of optical coherence tomography (OCT) called Fourier-Domain OCT with higher resolution and detailed imaging of the optic nerve head and the retinal nerve fiber layer (RNFL) is available. The aim of this study was to compare the established scanning laser ophthalmoscope (HRT3) with the Fourier-Domain OCT (RTVue-100).
One hundred eyes of 100 early glaucoma patients and 60 eyes of 60 healthy age matched controls were included. Early glaucoma was defined as a visual field typical for glaucoma with a mean deviation [MD] of ≤ 9 dB and/or pattern standard deviation [PSD] ≤ 8% and/or corrected loss variance [CLV] ≤ 64 dB² and a typical optic nerve head damage. Healthy controls had at least one normal reliable result on standard automated perimetry (SAP) and a normal optic nerve head. The area and the volume of the disc, cup and rim, the cup-disc-ratio, and the average of the RNFL were measured. A correlation of optic disc topographic parameters and RFNL was analysed using the Spearman-Rho-test. For discrimination between glaucoma and normal subjects receiver operating characteristic (ROC) curves were used.
The highest correlation between the instruments was shown with the parameters cup area (0.873), cup volume (0.848), disc area (0.748), and cup-disc-ratio (0.722). Discrimination between glaucoma patients and healthy subjects was better using the RTVue-100. The largest area under the ROC-curve (AUROC) for RTVue-100 was achieved with rim volume (0.819), rim area (0.816) and RNFL average (0.814). The largest AUROCs for HRT3 were cup-disc-ratio (0.738), cup area (0.702), rim area (0.675), and cup volume (0.649).
We found a good correlation between optic disc topographic measurements by RTVue-100 and HRT3. Diagnostic precision was better with the RTVue-100 compared to the HRT3. The Fourier-Domain-OCT is a useful tool for glaucoma diagnosis. Further studies will evaluate its usefulness in progression analysis.
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