April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
A Comparison of Local Retinal Ganglion Cell (RGC) Layer Thickness to Local Losses in Visual Field Sensitivity in Patients With Glaucoma
Author Affiliations & Notes
  • J. Cho
    Columbia University, New York, New York
  • A. S. Raza
    Columbia University, New York, New York
  • G. V. De Moraes
    New York Eye & Ear Infirmary, New York, New York
  • M. Wang
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • X. Zhang
    Columbia University, New York, New York
  • R. H. Kardon
    University of Iowa, Iowa City, Iowa
  • J. M. Liebmann
    New York Eye and Ear Infirmary, New York, New York
  • R. Ritch
    New York Eye & Ear Infirmary, New York, New York
  • D. C. Hood
    Columbia University, New York, New York
  • Footnotes
    Commercial Relationships  J. Cho, None; A.S. Raza, None; G.V. De Moraes, None; M. Wang, None; X. Zhang, None; R.H. Kardon, None; J.M. Liebmann, Topcon, F; Topcon, C; R. Ritch, None; D.C. Hood, Topcon, F; Topcon, C.
  • Footnotes
    Support  NIH/NEI Grant EY 02115
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4897. doi:
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      J. Cho, A. S. Raza, G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, D. C. Hood; A Comparison of Local Retinal Ganglion Cell (RGC) Layer Thickness to Local Losses in Visual Field Sensitivity in Patients With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4897.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To compare the loss in sensitivity measured with standard automated perimetry (SAP) to local retinal ganglion cell (RGC) layer thickness measured with frequency domain optical coherence tomography (fdOCT).

 
Methods:
 

The central ±10° region of 12 patients with glaucoma (7 NTG; 3 XFG; 2 POAG) was tested with SAP (10-2 SITA standard) and scanned with a fdOCT (3D-OCT 1000, Topcon) volume macular scan (6x6 mm region with 128 B-scans). 20 individuals with normal vision served as controls. To compare RGC thickness to SAP (TD: total deviation), two experienced readers segmented the RGC+ layer (i.e. RGC plus inner plexiform layer), as previously described,[1,2] for horizontal B-scans at 11 locations (0, ±1, ±3, ±5 ±7, and ±8°). To account for displacement of the RGC around the fovea, the field points were displaced to correspond to the location of the corresponding RGCs.[3] RGC+ thickness vs. SAP (TD) data were analyzed for 9 eccentricities from 1.4 to 9°.

 
Results:
 

RGC+ thickness correlated well (Spearman) with SAP loss within 6° of the fovea (r= 0.72 to 0.67). The correlation was worse (0.54 to 0.20) from 7° outward. A linear model [4] relating RGC+ thickness to linear SAP loss provided a reasonable fit (R²=0.56 to 0.45) for eccentricities less than 6°, but a poorer fit beyond (0.26 to -0.36). However, the fdOCT thickness associated with a given SAP loss tended to be lower than predicted by the model for smaller field losses.

 
Conclusions:
 

Within the central 6°, RGC+ layer thickness correlates with local sensitivity loss when the displacement of the RGCs is taken into consideration. The agreement becomes worse beyond 6°.1. Hood et al (2009) IOVS. 2. Wang et al (2009) Arch Ophthal. 3. Drasdo et al (2007) Vis Res; 4. Hood & Kardon (2007)  

 
Keywords: ganglion cells • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual fields 
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