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H. Huang, X. H. Sun; Correlating Structure of Retinal Nerve Fiber Layer With Function in Chinese Patients With Advanced Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4899.
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© ARVO (1962-2015); The Authors (2016-present)
To correlate structure of retinal nerve fiber layer with function in Chinese patients with advanced glaucoma.
A cross-sectional observational study.All patients underwent complete ophthalmic evaluation,including VF examination and imaging with fourier-domain optical coherence tomography(fdOCT).Three groups of patients(patients with the central 5-10 degrees of visual field,patients with the temporal peripheral field and normal) who satisfied the inclusion and exclusion criteria were included.Normal subjects had visual acuity >or= 20/30 and intraocular pressure<22 mmHg,with a normal optic disc and fields and no ocular abnormality.Average RNFL thickness and RNFL thickness in four quadrants and in 16 sections were measured using fourier-domain optical coherence tomography(fdOCT). 16sections were ST2(Superior Temporal),SN2(Superior Nasal),IT2(Inferior Temporal),IN2(Inferior Nasal),TU2(Temporal Upper),TL2 (Temporal Lower), NU2(Nasal Upper),NL2(Nasal Lower).
20 normal subjects,16 patients with central 5-10 degrees of visual field and 16 with temporal peripheral field were enrolled into the study.The remaining retinal nerve fiber layer measured in all patients with advanced glaucoma were:average 61.30±7.67µm,superior quadrant 78.05±9.66µm,inferior quadrant 80.02±11.91µm,nasal quadrant 44.54±9.44µm, temporal quadrant 42.60±9.68µm, the differences of RNFL thickness between normal and patients were significant (P<0.05). The average retinal nerve fiber layer measured in patients with central 5-10 degrees of visual field and temporal peripheral field were (60.99±8.20) um, (61.52±7.54)um respectively. There was no statistically significant difference in RNFL thickness between the two groups( P > 0. 05).In the eyes with central 5-10 degrees of visual field, temporal quadrant and 3 sections(TU1,TU2,TL2)thickness were higher than the other group. In the eyes with temporal peripheral field, nasal quadrant and 4 sections(SN2,NU2,NU1,NL1)thickness were higher than the other group. And the differences were statistically significant(P<0.05).
In eyes with advanced glaucoma,very thin but existing retinal nerve fiber layer is found on fdOCT. Such values rarely dropped below 20 to 30 µm, and the correlation between structure and function was positive.
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