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L. M. Pinto, E. F. Costa, P. B. Gross, M. M. Kavay, L. Fogaça, L. A. S. Melo, Jr., A. Paranhos, Jr.; Evaluation of Macular Structure and Function in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4913.
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To investigate and correlate the structural and functional macular changes in glaucoma using Time-Domain (TD-OCT), Fourier-Domain Optical Coherence Tomography (FD-OCT), Standard Automated Perimetry (SAP), and Frequency-Doubling Technology Perimetry (FDT Matrix).
Healthy and primary open-angle glaucoma individuals were enrolled in this observational, cross-sectional study. Macular structure was assessed with the Stratus OCT Fast Macular Thickness Scan, Cirrus OCT Macular Cube 512x128 and Spectralis OCT Macular Volume 20° x 20°. Macular function was assessed with the 10-2 Humphrey SAP and the 10.2 FDT Matrix. To make regional comparisons of these techniques each quadrant on the OCT macular thickness map were compared to the correspondent region on the visual field test. Correlation between macular OCT and visual field measurements were evaluated by Spearman's rank correlation test.
Eight-one eyes of 41 patients (8 normal, 33 glaucoma) were enrolled in the study (mean age 62.2 years, range 43-80).The mean (SD) values of the SAP in the superior, inferior, nasal and temporal regions were 25.6 (9.2), 28.6 (7.2), 27.3 (7.9) and 29.0 (6.0), respectively. The mean (SD) values of the FDT in the superior, inferior, nasal and temporal regions were 22.2 (8.5), 23.6 (7.2), 22.8 (7.9) and 24.7 (6.5), respectively. The macular thickness showed similar measurements in all regions for FD-OCTs. However the TD-OCT values were significantly thinner when compared to FD-OCTs. The correlation coefficients between OCTs and visual fields ranged from 0.40 and 0.73 (Table).
TD-OCT and FD-OCT results showed different correlation with visual field, which depended on the macular region evaluated. The strongest correlation was found between the inferior region on the OCTs and superior region in visual fields.
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