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I. M. Tavares, A. Kara-Jose, D. V. C. Barbosa, E. D. Almeida, Jr., M. T. Leite, A. T. N. H. Endo, C. R. S. Santos, L. A. S. Melo, Jr.; Retinal Nerve Fiber Layer Thickness and Visual Sensitivity Using Spectral-Domain and Time-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4923.
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To compare the strength of the structure-function association between retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and visual field sensitivity. In addition, the diagnostic accuracy of the Spectral Domain (SD) and Time Domain (TD) OCT were compared.
Thirty-six eyes of 19 healthy control subjects and 29 eyes of 15 patients with glaucoma (repeatable abnormal visual field by pattern standard deviation and/or glaucoma hemifield test) were included in this prospective, cross-sectional study. The participants were imaged with both SD-OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany) and TD-OCT (Stratus; Carl Zeiss Meditec, Inc., Dublin, CA) on the same day, and tested with Standard Automated Perimetry (SAP) (Humphrey Field Analyzer II with Swedish Interactive Thresholding Algorithm [SITA]; Carl Zeiss Meditec, Inc.) within an interval of one month. The correlation between RNFL thickness measurements (global, superior, nasal, inferior, temporal) with SD-OCT and TD-OCT and Mean Deviation (MD) visual field index was calculated using the Spearman's rank correlation coefficient (r). Areas under the receiver operating characteristic curve (AUROC) were used to evaluate the diagnostic accuracies of SD- and TD-OCT.
Regional structure-function correlations (r) ranged from 0.29 (nasal RNFL) to 0.48 (superior RNFL) for SD-OCT and from 0.20 (nasal RNFL) to 0.51 (superior RNFL) for TD-OCT. Correlations generally were slightly stronger for TD-OCT than for SD-OCT, although these differences were not significant (P ≥ 0.56) (table 1). The AUROC curve for the best parameter from SD-OCT (global RNFL) was slightly larger than that of the best parameter from the TD-OCT (global RNFL), but this difference was not significant (0.88 vs. 0.83, respectively; P = 0.10).
The RNFL thickness correlations with visual field sensitivity were similar using SD-OCT and TD-OCT. The diagnostic accuracy of SD-OCT was slightly better than that of TD-OCT.
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