April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Correlation Between Disc Damage Likelihood Scale and Cup-To-Disc Ratio, Visual Field and Retinal Nerve Fiber Layer Thickness in Normal and Glaucomatous Eyes
Author Affiliations & Notes
  • A. C. Kara-Jose
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • E. D. Almeida, Jr.
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • L. A. Melo, Jr.
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • D. V. C. Barbosa
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • M. T. Leite
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • A. T. N. H. Endo
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • C. R. S. Santos
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • I. M. Tavares
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4925. doi:
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    • Get Citation

      A. C. Kara-Jose, E. D. Almeida, Jr., L. A. Melo, Jr., D. V. C. Barbosa, M. T. Leite, A. T. N. H. Endo, C. R. S. Santos, I. M. Tavares; Correlation Between Disc Damage Likelihood Scale and Cup-To-Disc Ratio, Visual Field and Retinal Nerve Fiber Layer Thickness in Normal and Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4925.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine the correlation between Disc Damage Likelihood Scale (DDLS) and cup-to-disc ratio, visual field mean deviation (MD) index and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes.

 
Methods:
 

Forty-one eyes of 21 healthy subjects and 33 eyes of 17 patients with Primary Open-Angle Glaucoma with repeatable abnormal visual fields were included in this prospective, cross-sectional study. DDLS score and cup-to-disc ratio were evaluated by a trained physician using a 78-diopter lens. The visual field was examined by Standard Automated Perimetry Swedish Interactive Thresholding Algorithm (SITA) Standard 24-2 test (HFA II; Carl Zeiss Meditec, Dublin, CA, U.S.A.). The RNFL thickness was measured by Time-Domain Optical Coherence Tomography (TD-OCT) (Stratus; software version 5.0.1, Carl Zeiss Meditec, California, USA) and Spectral-Domain OCT (SD-OCT; Spectralis; software version 4.0, Heidelberg Engineering, Dossenheim, Germain). Correlations between DDLS score and cup-to-disc ratio, visual field MD index and RNFL average thickness were analyzed by Spearman's rank correlation coefficient (r).

 
Results:
 

Table 1 shows the mean and standard deviation for the studied parameters. A strong positive correlation was found between DDLS and cup-to-disc ratio (Spearman r = 0.82; P < 0.001). Weaker correlations were found between DDLS and visual field MD index (r = - 0.51; P < 0.001), Stratus RNFL average thickness (r = - 0.62; P < 0.001) and Spectralis RNLF average thickness ( r = - 0.63; P < 0.001).

 
Conclusions:
 

The present study showed that the DDLS is significantly correlated with both structural and functional parameters.  

 
Keywords: optic disc • nerve fiber layer • visual fields 
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