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M. K. Klamann, A. Grünert, A.-K. B. Maier, F. M. A. Heussen, S. Winterhalter, A. M. Joussen, K. K. Huber; Comparison of Functional and Morphological Diagnostics in Glaucoma Patients and Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4927.
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To investigate the correlation between microperimetry (MP, MP-1, Nidek Technologies), blue-on-yellow-perimetry (B/YP, Octopus, Haag-Streit), confocal scanning laser ophthalmoscopy (HRT III) and optical coherence tomography (OCT 3) in early glaucoma and to evaluate the diagnostic value of MP, B/YP, HRT III and OCT 3 in discriminating glaucoma from normal eyes.
Prospective examination of 22 eyes of subjects with early primary open angle glaucoma and 24 eyes of normal control subjects. The control group was age and gender matched. After a complete ophthalmological examination B/YP, MP, OCT 3 and HRT III were determined. The morphological (OCT 3 and HRT III) and functional parameters (B/YP and MP) were compared.
The mean sensitivity threshold values obtained with B/YP and MP did not show significant differences between glaucoma patients and the control group (p=0.32 and p=0.28). The correlation between mean sensitivity threshold measured by B/YP and MP was significant (r=0.606, p<0.001). RNFL-thickness was found to be significantly decreased in patients with glaucoma with both HRT III and OCT 3 (p=0.018 and p<0.001). A significant correlation between RNFL-thickness measured with HRT III and OCT 3 was found (r=0.488, p=0.001). There was neither a good correlation between HRTIII RNFL-thickness and B/YP mean sensitivity threshold (r=0.103, p=0.497), nor a good correlation between RNFL-thickness measured by OCT 3 and B/YP (r=0.089, p=0.555). A significant correlation between RNFL-thickness measured with HRT III and MP mean sensitivity threshold was found (r=0.300, r=0.043) as well as a significant correlation between RNFL-thickness measured with OCT 3 and MP (r=0.307, r=0.038).
While B/YP and MP had no ability to discriminate between subjects with early glaucoma and healthy subjects, RNFL-thickness measured with HRT III and OCT 3 showed a significant difference. In early primary open angle glaucoma morphological changes like RNFL-thickness seem to occur prior to functional defects in VF.
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