Abstract
Purpose: :
To investigate the correlation between microperimetry (MP, MP-1, Nidek Technologies), blue-on-yellow-perimetry (B/YP, Octopus, Haag-Streit), confocal scanning laser ophthalmoscopy (HRT III) and optical coherence tomography (OCT 3) in early glaucoma and to evaluate the diagnostic value of MP, B/YP, HRT III and OCT 3 in discriminating glaucoma from normal eyes.
Methods: :
Prospective examination of 22 eyes of subjects with early primary open angle glaucoma and 24 eyes of normal control subjects. The control group was age and gender matched. After a complete ophthalmological examination B/YP, MP, OCT 3 and HRT III were determined. The morphological (OCT 3 and HRT III) and functional parameters (B/YP and MP) were compared.
Results: :
The mean sensitivity threshold values obtained with B/YP and MP did not show significant differences between glaucoma patients and the control group (p=0.32 and p=0.28). The correlation between mean sensitivity threshold measured by B/YP and MP was significant (r=0.606, p<0.001). RNFL-thickness was found to be significantly decreased in patients with glaucoma with both HRT III and OCT 3 (p=0.018 and p<0.001). A significant correlation between RNFL-thickness measured with HRT III and OCT 3 was found (r=0.488, p=0.001). There was neither a good correlation between HRTIII RNFL-thickness and B/YP mean sensitivity threshold (r=0.103, p=0.497), nor a good correlation between RNFL-thickness measured by OCT 3 and B/YP (r=0.089, p=0.555). A significant correlation between RNFL-thickness measured with HRT III and MP mean sensitivity threshold was found (r=0.300, r=0.043) as well as a significant correlation between RNFL-thickness measured with OCT 3 and MP (r=0.307, r=0.038).
Conclusions: :
While B/YP and MP had no ability to discriminate between subjects with early glaucoma and healthy subjects, RNFL-thickness measured with HRT III and OCT 3 showed a significant difference. In early primary open angle glaucoma morphological changes like RNFL-thickness seem to occur prior to functional defects in VF.
Keywords: visual fields • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic nerve