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C. Schuetze, C. Ahlers, B. Baumann, M. Pircher, E. Götzinger, R. Donner, J. Ofner, C. Hitzenberger, U. Schmidt-Erfurth; Automatic Segmentation of Subretinal Fluid in Patients With Choroidal Neovascularization Using Polarization-Sensitive Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4935.
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Aim of this prospective follow-up survey was the automatic three-dimensional detection of subretinal fluid in patients with choroidal neovascularization (CNV) using polarization-sensitive optical coherence tomography (PS-OCT).
Ten eyes of 10 patients with CNV revealing subretinal fluid at their baseline visit, being treated with an anti-VEGF agent over 6 months, were included. Three-dimensional automatic detection of subretinal fluid was performed by PS-OCT, applying a specifically developed software algorithm.
Three-dimensional analysis and automatic detection of subretinal fluid was carried out for the first time, using PS-OCT. This technique revealed a reduction in subretinal fluid volume after 1, 3 and 6 months, indicating therapeutic success when anti-VEGF is applied. These findings correspond to manual segmentation studies.
PS-OCT has previously demonstrated to be capable of imaging the retinal pigment epithelium (RPE) and similar melanin-containing structures, based on their specific polarization properties. This study shows the potential of automatic three-dimensional segmentation in subretinal fluid detection by PS-OCT in patients with neovascular age-related macular degeneration (nAMD). These findings may be clinically relevant in terms of therapeutic follow-up analysis, as subretinal fluid characteristics were shown to be prognostically and functionally relevant parameters in patients with nAMD.
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