April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Analysis of Corneal Wavefront Aberrations for Differentiation Between Keratoconus, Pellucid Marginal Degeneration and Normal Eyes
Author Affiliations & Notes
  • D.-L. Ott
    Department of Ophthalmology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
  • J. Buehren
    Department of Ophthalmology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
  • O. K. Klaproth
    Department of Ophthalmology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
  • R. Schwarz
    Cambridge Research Institute, Cambridge, United Kingdom
  • T. Kohnen
    Department of Ophthalmology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas
  • Footnotes
    Commercial Relationships  D.-L. Ott, None; J. Buehren, None; O.K. Klaproth, None; R. Schwarz, None; T. Kohnen, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4975. doi:
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      D.-L. Ott, J. Buehren, O. K. Klaproth, R. Schwarz, T. Kohnen; Analysis of Corneal Wavefront Aberrations for Differentiation Between Keratoconus, Pellucid Marginal Degeneration and Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4975.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the ability of wavefront aberrations of the anterior and posterior corneal surface to discriminate between eyes with keratoconus (KC), pellucid marginal degeneration (PMD) and normal eyes.

Methods: : This study included 55 eyes of 32 patients with KC, 60 eyes of 43 patients with PMD and 64 eyes of 32 subjects with normal eyes.From axial-keratometric data of the anterior corneal surface and elevation data (Orbscan IIz, Bausch & Lomb) of the posterior corneal surface a Zernike decomposition (2nd - 7th order, 6 mm pupil diameter) was performed. Discriminative ability of individual Zernike coefficients was assessed by receiver operating characteristic curve (ROC) analysis.

Results: : The comparison of the anterior corneal surface between KC and PMD eyes showed highest discriminative power (standardized area under the ROC curve [AzROC]) for the coefficient C22 (AzROC=0.891), between KC and normal eyes for total higher-order aberrations root mean square (HOA RMS) value (AzROC=0.971) and between PMD and normal eyes for the coefficient C3-1 (AzROC=0.991). For the posterior corneal surface C3-1 (AzROC=0.816) discriminated best between KC and PMD eyes, and the RMS value of all non-coma, non-spherical HOA was found to discriminate best between both normal and KC eyes (AzROC=0.967) and normal and PMD eyes (AzROC=0.963).

Conclusions: : Zernike coefficients from the anterior and posterior corneal surface could be used as parameters to discriminate between normal, KC and PMD eyes with high accuracy. Discriminative ability of anterior corneal aberrations was higher than that of posterior corneal aberrations.

Keywords: keratoconus • cornea: clinical science • aberrations 
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