April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Usability of the New Waveform Parameters From the Ocular Response Analyzer in the Characterization of Keratoconus
Author Affiliations & Notes
  • R. Michael
    Institut Universitari Barraquer, Barcelona, Spain
  • M. Mikielewicz
    Institut Universitari Barraquer, Barcelona, Spain
  • K. Kotliar
    Department of Ophthalmology, Munich University of Technology, Munich, Germany
  • R. I. Barraquer
    Institut Universitari Barraquer, Barcelona, Spain
  • Footnotes
    Commercial Relationships  R. Michael, None; M. Mikielewicz, None; K. Kotliar, None; R.I. Barraquer, None.
  • Footnotes
    Support  FIS PI08/90726
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4984. doi:
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      R. Michael, M. Mikielewicz, K. Kotliar, R. I. Barraquer; The Usability of the New Waveform Parameters From the Ocular Response Analyzer in the Characterization of Keratoconus. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4984.

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Abstract

Purpose: : To test the usability of 39 new waveform parameters from ORA to distinguish between normal and keratoconus (KC) eyes, to determine the severity of keratoconus and to evaluate changes after treatment with crosslinking and intrastromal ring segment implantation.

Methods: : Forty waveform parameters were derived from ORA's aplanation signal curve. Data of 119 subjects were included in the study. We examined the power of discrimination between control subjects (n=48) and KC patients (stages I & II, n=54) using ROC curves. Subsequently the correlation between KC stages and the waveform parameters was tested. Finally, the changes at 4 months after the treatment with crosslinking (n=22) and intrastromal rings (n=39) were evaluated.

Results: : The ROC curves of 11 parameters showed excellent results, 22 moderate and 6 parameters proved to give poor results. Although 15 of the parameters demonstrated statistically significant results (p<0.05) the correlations between KC stages and parameters were only moderate (r<0.5). After crosslinking one parameter and after intrastromal ring implantation two parameters showed significant difference between pre and postoperative values (p<0.05).

Conclusions: : Most of the new waveform parameters demonstrated good ability to discriminate between keratoconus and normal eyes. The ability to detect the severity of keratoconus was moderate. The changes in the parameter values after treatment were smaller than expected.

Keywords: keratoconus 
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