April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Screening of Keratoconus and Keratoconus Suspects Using Rotating Scheimpflug Corneal Topography
Author Affiliations & Notes
  • M. Shimabukuro
    Yukoukai general hospital, Ibaraki, Japan
  • R. Higashiura
    Osaka Unversity, Suita, Japan
  • M. Fuchihata
    Osaka Unversity, Suita, Japan
  • T. Nakagawa
    Osaka Unversity, Suita, Japan
  • S. Koh
    Osaka Unversity, Suita, Japan
  • T. Inoue
    Osaka Unversity, Suita, Japan
  • N. Maeda
    Osaka Unversity, Suita, Japan
  • Footnotes
    Commercial Relationships  M. Shimabukuro, None; R. Higashiura, None; M. Fuchihata, None; T. Nakagawa, None; S. Koh, None; T. Inoue, None; N. Maeda, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4992. doi:
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      M. Shimabukuro, R. Higashiura, M. Fuchihata, T. Nakagawa, S. Koh, T. Inoue, N. Maeda; Screening of Keratoconus and Keratoconus Suspects Using Rotating Scheimpflug Corneal Topography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4992.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare three screening programs for keratoconus (KC) and keratoconus suspects (KCS) with corneal height data using rotating scheimpflug corneal topography.

Methods: : Corneal topographic analysis was performed using the Pentacam (Oculus, Wetzlar, Germany) in 36 eyes with KC, 50 that were KCS, and 50 normal controls. Three screening programs (anterior Zernike, Belin/Ambrosio, and posterior peak-to-valley value of the central 4-mm diameter) were compared for sensitivity, specificity, and the receiver operating characteristics (ROC) curve.

Results: : The sensitivities for KC with the anterior Zernike, Belin/Ambrosio, and posterior peak-to-valley value programs were 100%, 100%, and 97%, respectively, with no significant differences among them; the sensitivities for KCS were 20%, 54%, and 50%, respectively. The Belin/Ambrosio and posterior peak-to-valley values programs were significantly (p=0.009, 0.002) better than the anterior Zernike program. The specificities with the three programs were 94%, 86%, and 98%, respectively. The highest area under the ROC curve was obtained with the posterior peak-to-valley value program.

Conclusions: : Although corneal height data accurately discriminated KC from normal controls and the Belin/Ambrosio and posterior peak-to-valley values programs are currently more useful than the anterior Zernike program for detecting KCS, the programs must be refined to differentiate eyes with KCS from normal eyes.

Keywords: keratoconus • topography • cornea: stroma and keratocytes 
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