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M. Shimabukuro, R. Higashiura, M. Fuchihata, T. Nakagawa, S. Koh, T. Inoue, N. Maeda; Screening of Keratoconus and Keratoconus Suspects Using Rotating Scheimpflug Corneal Topography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4992.
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© ARVO (1962-2015); The Authors (2016-present)
To compare three screening programs for keratoconus (KC) and keratoconus suspects (KCS) with corneal height data using rotating scheimpflug corneal topography.
Corneal topographic analysis was performed using the Pentacam (Oculus, Wetzlar, Germany) in 36 eyes with KC, 50 that were KCS, and 50 normal controls. Three screening programs (anterior Zernike, Belin/Ambrosio, and posterior peak-to-valley value of the central 4-mm diameter) were compared for sensitivity, specificity, and the receiver operating characteristics (ROC) curve.
The sensitivities for KC with the anterior Zernike, Belin/Ambrosio, and posterior peak-to-valley value programs were 100%, 100%, and 97%, respectively, with no significant differences among them; the sensitivities for KCS were 20%, 54%, and 50%, respectively. The Belin/Ambrosio and posterior peak-to-valley values programs were significantly (p=0.009, 0.002) better than the anterior Zernike program. The specificities with the three programs were 94%, 86%, and 98%, respectively. The highest area under the ROC curve was obtained with the posterior peak-to-valley value program.
Although corneal height data accurately discriminated KC from normal controls and the Belin/Ambrosio and posterior peak-to-valley values programs are currently more useful than the anterior Zernike program for detecting KCS, the programs must be refined to differentiate eyes with KCS from normal eyes.
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