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S. L. Wang, A. J. Kanellopoulos; Novel Cornea OCT Findings in Early and Long Term Follow Up of Collagen Cross-Linking for Keratoconus. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4993.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate novel, reproducible cornea OCT (cOCT) findings the first 6 months and at least 3 years following collagen cross-linking (CXL) for keratoconus (KCN).
125 KCN patients (Laservision.gr Institute, Athens, Greece) who had been treated with CXL recently (group A) or earlier (group B) were enrolled in the study. They were evaluated in follow-up for: the presence and stromal depth of intrastromal CXL lines (I-CXL-l) using cOCT, corneal thickness in microns (CT), uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), keratometry (K), topography, endothelial cell count (ECC), and clarity.
The mean follow-up time was 7 months (group A) and 38 months (group B). 68 of 71 patients in Group A and 51 of 54 in group B demonstrated I-CXL-l. The mean values for group A and group B were respectively: I-CXL-l depth: 255, 262; CT: 370, 380; UCVA: 20/60, 20/50; BSCVA: 20/40, 20/30; K: 49.5, 48.5; ECC: 2550, 2600.
cOCT appears to demonstrate reproducible early and long-term corneal findings in eyes treated with CXL, suggesting the use of cOCT as a possible novel non-invasive measurement to evaluate and titrate intrastromal effects of this treatment in KCN eyes.
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