April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Influence of Change in Body Position on Choroidal Blood Flow in Patients With Obstructive Sleep Apnea Syndrome
Author Affiliations & Notes
  • M. Tonini
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • H. Khayi
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • J. Pepin
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • E. Renard
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • P. Levy
    Pneumology,
    Grenoble University Hospital, Grenoble, France
  • J. Romanet
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • M. Geiser
    Optic, Haute Ecole valaisanne, Sion, Switzerland
  • C. Chiquet
    Department of Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • Footnotes
    Commercial Relationships  M. Tonini, None; H. Khayi, None; J. Pepin, None; E. Renard, None; P. Levy, None; J. Romanet, None; M. Geiser, None; C. Chiquet, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5016. doi:
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      M. Tonini, H. Khayi, J. Pepin, E. Renard, P. Levy, J. Romanet, M. Geiser, C. Chiquet; Influence of Change in Body Position on Choroidal Blood Flow in Patients With Obstructive Sleep Apnea Syndrome. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5016.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Obstructive sleep apnea syndrome (OSA) has been reported to be associated with ischemic and glaucomatous optic neuropathy (especially normal tension glaucoma). OSA per se is able to generate hypertension, atherosclerosis and autonomic dysfunction, all conditions possibly interacting with ocular vascular regulation. The aim of our study was to characterize the choroidal vascular reactivity to change in body position in OSA patients, as compared with matched healthy control subjects.

Methods: : Eighteen newly diagnosed OSA patients were included in this prospective study. Control subjects were matched with OSA patients for body mass index (BMI), gender and age. At the screening visit, each subject underwent a general exam, cardiovascular, neurologic and ophthalmological examinations, and overnight polysomnography.The LDF instrument used in this study to measure subfoveal choroidal blood flow (ChBF), ChBVel , velocity (kHz); and volume, ChBVol (in arbitrary units, AU) Vascular choroidal reactivity was tested during the change in body position from the sitting to the supine position (10 min).

Results: : OSA patients exhibited a similar choroidal reactivity during change in body position than controls with increased ChBVel (+14%), decreased ChBVol (-12%), and unchanged ChBF.

Conclusions: : This prospective comparative study showed for the first time unimpaired choroidal vascular reactivity in otherwise healthy OSA patients. This suggests OSA patients, without comorbidities, has long-term adaptive mechanisms active in ocular microcirculation.

Keywords: choroid • hypoxia • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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