April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Phosphodiesterase Inhibitor Moxaverine Increases Ocular Blood Flow in Patients With Age-Related Macular Degeneration and in Age-Matched Healthy Subjects
Author Affiliations & Notes
  • B. Pemp
    Department of Clinical Pharmacology,
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • D. Schmidl
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • M. Lasta
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • G. Weigert
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • G. Garhofer
    Department of Clinical Pharmacology,
    Medical University of Vienna, Vienna, Austria
  • L. Schmetterer
    Department of Clinical Pharmacology,
    Center for Biomedical Engineering and Physics,
    Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  B. Pemp, Ursapharm Arzneimittel GmbH, R; D. Schmidl, None; M. Lasta, None; G. Weigert, None; G. Garhofer, None; L. Schmetterer, None.
  • Footnotes
    Support  This study was supported by an unrestricted research grant from Ursapharm Arzneimittel GmbH, Saarbrücken, Germany
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5034. doi:
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      B. Pemp, D. Schmidl, M. Lasta, G. Weigert, G. Garhofer, L. Schmetterer; The Phosphodiesterase Inhibitor Moxaverine Increases Ocular Blood Flow in Patients With Age-Related Macular Degeneration and in Age-Matched Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5034.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Results from recent studies have shown that the unspecific phosphodiesterase inhibitor moxaverine increases choroidal blood flow (ChBF) in young healthy subjects and in patients with primary open angle glaucoma. There is some evidence that reduced ChBF may contribute to the development of age-related macular degeneration (AMD). Therefore we tested whether moxaverine increases ocular blood flow in patients with AMD and in control subjects with healthy eyes.

Methods: : 20 patients with dry AMD and 20 age-matched healthy subjects were included in this study. 150 mg moxaverine was administrated intravenously over 30 minutes. Retinal vessel diameters were measured using the Dynamic Vessel Analyzer, ChBF and optic nerve head blood flow (ONHBF) were measured using laser-Doppler flowmetry, retrobulbar blood velocities were assessed using colour Doppler imaging. Measurements were performed before and 30, 60 and 90 minutes after the start of drug administration.

Results: : Moxaverine increased ChBF by 10 ± 23% (p = 0.050), ONHBF by 15 ± 33% (p = 0.049), mean flow velocity (MFV) in the ophthalmic artery by 27 ± 39% (p < 0.001) and MFV in posterior ciliary arteries by 30 ± 39% (p 0.30). Moxaverine had no effect on retinal vessel diameters.

Conclusions: : A single dose of systemic moxaverine increases ocular blood flow in patients with AMD and in age-matched subjects with healthy eyes. Further studies are needed to investigate whether a long-term use of moxaverine is beneficial in treatment or prevention of AMD.

Clinical Trial: : www.clinicaltrials.gov NCT00709449

Keywords: drug toxicity/drug effects • blood supply • age-related macular degeneration 
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