April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Local Relationships Between Retinal Thickness and Functional Changes in Diabetes
M. A. Bearse, Jr.; K. Dhamdhere; W. W. Harrison; K. Bronson-Castain; S. Barez; M. E. Schneck; A. J. Adams
Author Affiliations & Notes
  • M. A. Bearse, Jr.
    School of Optometry, University of California, Berkeley, California
  • K. Dhamdhere
    School of Optometry, University of California, Berkeley, California
  • W. W. Harrison
    School of Optometry, University of California, Berkeley, California
  • K. Bronson-Castain
    School of Optometry, University of California, Berkeley, California
  • S. Barez
    School of Optometry, University of California, Berkeley, California
  • M. E. Schneck
    School of Optometry, University of California, Berkeley, California
  • A. J. Adams
    School of Optometry, University of California, Berkeley, California
  • Footnotes
    Commercial Relationships  M.A. Bearse, Jr., None; K. Dhamdhere, None; W.W. Harrison, None; K. Bronson-Castain, None; S. Barez, None; M.E. Schneck, None; A.J. Adams, None.
  • Footnotes
    Support  NIH Grant EY02271 to AJA
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5070. doi:
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      M. A. Bearse, Jr., K. Dhamdhere, W. W. Harrison, K. Bronson-Castain, S. Barez, M. E. Schneck, A. J. Adams; Local Relationships Between Retinal Thickness and Functional Changes in Diabetes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5070.

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Abstract

Purpose: : To study the local relationships between retinal thickness assessed by optical coherence tomography (OCT) and retinal function measured with multifocal electroretinography (mfERG) in adult patients with diabetes (DM) and no retinopathy.

Methods: : We studied 36 patients with no retinopathy (9 with type 1 DM; 27 with type 2 DM; mean age = 50.0 +/- 11.8 yrs) and 29 healthy control subjects (47.0 +/- 12.8 yrs). The central 20 deg of one eye of each subject was examined. The amplitude (AMP) and P1 implicit time (IT) of each of the central 37 first order mfERGs were derived using a template scaling method (Hood & Li, 1997). These were compared to spatially corresponding retinal thickness measurements (Stratus OCT 3). To account for variation with eccentricity, retinal thickness was converted to percentile rank, and AMP and IT were converted to Z-scores based on control data. Local abnormalities were defined as P-values <= 0.023. Retinal thickness was compared to AMP and IT using Chi-square analyses to determine whether structure and function were locally associated.

Results: : IT was positively associated with retinal thickness in the type 1 group (P<0.001) and marginally in the type 2 group (P=0.025), but not in the control group (P>0.05). AMP was positively associated with retinal thickness in the type 1 group (P<0.001) and the control group (P<0.005) but not in the type 2 group (P>0.05). As expected, the type 1 and type 2 groups had more abnormal locations than the control group. IT abnormalities were not spatially associated with retinal thickness abnormalities in any subject group (P>0.05). Abnormally thin retinal locations were associated with abnormally small AMP (P=0.012) in the type 2 group but not in the other subject groups.

Conclusions: : Relationships between local retinal thickness measured with OCT and function assessed with mfERG are complex. For example, although longer mfERG implicit times are associated with retinal thickening in diabetes, there is not a significant spatial agreement between the two measurements in their classification of abnormalities. In addition, the associations are not necessarily monotonic, especially in type 2 diabetes.

Keywords: diabetes • electroretinography: clinical • diabetic retinopathy 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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