April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Resveratrol Suppresses Ocular Inflammation in the Diabetic Retina
Author Affiliations & Notes
  • S. Kubota
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
    Keio University, Tokyo, Japan
  • T. Kurihara
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
    Keio University, Tokyo, Japan
  • K. Noda
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
    Keio University, Tokyo, Japan
  • Y. Ozawa
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
    Keio University, Tokyo, Japan
  • Y. Oike
    Laboratory of Retinal Cell Biology,
    Keio University, Tokyo, Japan
    Molecular Genetics, Kumamoto University, Kumamoto, Japan
  • S. Ishida
    Laboratory of Retinal Cell Biology,
    Keio University, Tokyo, Japan
    Ophthalmology, Hokkaido Univ Graduate School of Med, Sapporo, Japan
  • K. Tsubota
    Department of Ophthalmology,
    Keio University, Tokyo, Japan
  • Footnotes
    Commercial Relationships  S. Kubota, None; T. Kurihara, None; K. Noda, None; Y. Ozawa, None; Y. Oike, None; S. Ishida, None; K. Tsubota, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5082. doi:
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    • Get Citation

      S. Kubota, T. Kurihara, K. Noda, Y. Ozawa, Y. Oike, S. Ishida, K. Tsubota; Resveratrol Suppresses Ocular Inflammation in the Diabetic Retina. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5082.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Resveratrol is known as one of the dietary polyphenols found in red wine and grape skin. It has been reported that resveratrol prevents tumorigenesis and aging; however, the effect of resveratrol on ocular pathology still remains unclear. In this study, we investigated the anti-inflammatory role of resveratrol in the diabetic retina.

Methods: : C57BL/6 mice with streptozotocin-induced diabetes were orally treated with resveratrol at the dose of 50mg/kg for seven days. Leukocyte adhesion to the retinal vasculature was evaluated with the concanavalin A lectin perfusion-labeling technique. Retinal protein levels of intercellular adhesion molecule (ICAM)-1 and VEGF were examined by ELISA.

Results: : Administration of resveratrol significantly (P < 0.01) reduced leukocyte adhesion to the retinal vessels of diabetic mice by 40%. In addition, the diabetic animals treated with resveratrol showed a significant (P < 0.01) decrease in retinal ICAM-1and VEGF, which were upregulated following the induction of diabetes.

Conclusions: : Resveratrol suppressed leukocyte adhesion together with the inflammatory molecules in the diabetic model. The current data suggest the potential use of resveratrol as a therapeutic agent for diabetic retinopathy.

Keywords: diabetic retinopathy • diabetes 
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