April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Endoresection for Large Choroidal Melanoma After Proton Beam: Preliminary Results
Author Affiliations & Notes
  • N. Cassoux
    Ophthalmology, Hopital Pitie-Salpetriere,Institut Curie, Paris, France
  • S. Cayette
    Ophthalmology, Hopital Pitie-Salpetriere,Institut Curie, Paris, France
  • L. Lumbroso-Le Rouic
    Institut Curie, Paris, France
  • C. Levy
    Institut Curie, Paris, France
  • B. Asselin
    Institut Curie, Paris, France
  • R. Dendale
    Institut Curie, Paris, France
  • P. Lehoang
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • L. Desjardins
    Institut Curie, Paris, France
  • Footnotes
    Commercial Relationships  N. Cassoux, None; S. Cayette, None; L. Lumbroso-Le Rouic, None; C. Levy, None; B. Asselin, None; R. Dendale, None; P. Lehoang, None; L. Desjardins, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5147. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      N. Cassoux, S. Cayette, L. Lumbroso-Le Rouic, C. Levy, B. Asselin, R. Dendale, P. Lehoang, L. Desjardins; Endoresection for Large Choroidal Melanoma After Proton Beam: Preliminary Results. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5147.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : to evaluate the benefits of endoresection for large choroidal melanoma after proton beam irradiation in reducing the rate of secondary enucleation.

Methods: : Monocentric prospective study. Were included patients with large choroidal melanoma of at least 6mm in thickness. Surgery was done 3 months or more after proton beam irradiation. Were excluded patients in witch a primary enucleation was recommended, tumors that invade the optic nerve head or ciliary body, contra indication for general anaesthesia. Endoresection was performed after pars plana vitrectomy followed by a silicon oil tamponade.

Results: : since the 1st of January 08, 48 patients mean age 55 year-old (17-81 y-o) were included. Median time between irradiation and surgery was 4.4 months (2-12 m). Mean tumor diameter was 13.9 mm (2.7-19 mm), mean tumor thickness was 8.6 mm (6.3-12.2mm). Before surgery 91.8% of patients presented a retinal detachment. Neovascular glaucome was present for 2 patients. Tumor was removed and retina was reattached in all the patients except for 2 of them. Post operative complications included hyphema in 10.20%, retinal detachment relapse in 6.1%. No neovascular glaucoma, no local recurrence of the tumor, were observed after a mean follow-up of 11 months (2-21 months).

Conclusions: : These preliminary results showed that endoresection is a safe procedure after proton beam irradiation and can improve eye retention for the biggest tumors.

Clinical Trial: : curie 00012

Keywords: tumors • melanoma • radiation therapy 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.