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G. D. Willerding, D. Cordini, L. Moser, N. E. Bechrakis, M. H. Foerster; Proton Beam Therapy of Iris Melanoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5155.
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© ARVO (1962-2015); The Authors (2016-present)
To report the results of proton beam therapy of iris melanoma.
Retrospective, interventional, consecutive, single-institution case series.
54 patients were treated between Oct. 1998 and Nov. 2008 with a dose of 4x15 CGE proton beam. 51 Patients received whole-iris irradiation due to presumed diffuse tumor spread. Mean patient age was 54 years. Mean follow up is 39 months. Tumor control was achieved in 53 cases. Complications included secondary enucleation in one case, cataract in any case with a minimum follow up of 12 months and secondary glaucoma in 34 patients.
Proton beam therapy offers a high rate of tumor control in this subset of patients. Cataract and glaucoma appear to be very common after treatment.
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