April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Histopathological Evaluation of Pigmented Intraocular Tumors in Dogs
Author Affiliations & Notes
  • E. Perlmann
    Comparative Ophthalmology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
  • P. S. M. Barros
    Comparative Ophthalmology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
  • L. Fernandez
    Ophthalmology, School of Medicine, McGill University, Montreal, Quebec, Canada
  • S. Di Cesare
    Ophthalmology, School of Medicine, McGill University, Montreal, Quebec, Canada
  • S. Bakalian
    Ophthalmology, School of Medicine, McGill University, Montreal, Quebec, Canada
  • M. N. Burnier, Jr.
    Ophthalmology, School of Medicine, McGill University, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships  E. Perlmann, None; P.S.M. Barros, None; L. Fernandez, None; S. Di Cesare, None; S. Bakalian, None; M.N. Burnier, Jr., None.
  • Footnotes
    Support  Supported by CNPq grant 501494/2005-7 and CAPES (fellowship Dr Perlmann)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5159. doi:https://doi.org/
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      E. Perlmann, P. S. M. Barros, L. Fernandez, S. Di Cesare, S. Bakalian, M. N. Burnier, Jr.; Histopathological Evaluation of Pigmented Intraocular Tumors in Dogs. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5159. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Introduction: : Background: Benign and malignant tumors of melanocytic origin are the most common primary canine intraocular neoplasms, representing an important disease in the veterinary community. They have distinct distribution, clinical features and prognosis when compared to human melanocytic neoplasms. In this report, we aimed to study a series of pigmented tumors of dogs and classify them based on histopathological criteria.

Methods: : A series of canine intraocular pigmented tumors was reviewed. Formalin-fixed, paraffin-embedded specimens were cut and stained with H&E. Bleached sections were also prepared in order to evaluate cytological features. Histopathological parameters that were studied included tumor location, degree of pigmentation (negative, + or ++), extent of tumoral necrosis (negative, + or ++) and final diagnosis.

Results: : The data consisted of 22 eyes of 22 dogs. Sixteen tumors were anterior (iris and ciliary body), while the other 6 involved the entire eye. The majority of specimens were heavily pigmented (n=16) while the remaining specimens (n=6) were mildly pigmented. There were no amelanotic cases. Fifteen cases showed extensive necrosis, 6 cases had limited necrosis, and one case had no necrosis. Half of the samples (n=11) were considered benign and all of those were melanocytomas. The malignant group was composed of 10 melanomas (2 spindle, 3 mixed, 5 epithelioid) and 1 adenocarcinoma of the ciliary epithelium. Of the 10 melanoma cases, five had areas that were histopathologically identified as melanocytomas.

Conclusions: : We presented a large series of canine intraocular pigmented tumors. There was a striking predilection for the anterior part of the eye. Most tumors were heavily pigmented and the majority showed extensive areas of necrosis. The proportion of melanocytomas is much greater than what is reported in humans. Half of the melanomas seemed to have arisen from melanocytomas, suggesting that these benign tumors can undergo malignant transformation.

Keywords: melanoma • tumors 
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