Purchase this article with an account.
J. Wang, R. Spencer, J. N. Leffler, E. E. Birch; Frequency Domain OCT Foveal Fine Structure in Children With Regressed Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5223.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Because 24-28 weeks gestation is a critical period for vascularization in the macular region and formation of the foveal avascular zone (Provis & Henrickson, 2008), the maturing anatomy of the fovea could depend on gestational age. Increased foveal total thickness has been reported in 5 adults with regressed ROP born at 24-28 weeks compared with normal controls (Hammer et al, IOVS 2008). We explored the relationship between the severity of foveal abnormalities in children with regressed ROP and their gestational age, birth weight and visual acuity.
Two groups of children aged 5-18 years (regressed ROP group with normal-appearing posterior pole: n=32; full-term control group: n=33) were studied. A frequency domain OCT (Spectralis, Heidelberg) 9mm line scan across the fovea was obtained from both eyes in the ROP group and the right eye in the control group. Using a custom MatLab program, total thickness in the center and at eccentricities of ±1°, ±2°, ±3° were measured. In addition, inner and outer foveal layers were segmented and measured. Visual acuity was measured with E-ETDRS at the same visit. Gestational age (23.7-32; 27.3±2.6 weeks) and birth weight (965±406 grams) were obtained from medical records. Data from nonamblyopic eyes (right: n=24; left: n=20) were combined for analysis.
The total thickness of the central fovea in the ROP group (287.7±47.6µm) was thicker than in the control group (230.1±18.2 µm) (p<0.001). At ±1° and ±2° eccentricity, there were significant differences between the ROP and control groups (p<0.05), but not at ±3° eccentricity (p=0.58) (extrafoveal). Central total thickness was significantly correlated with gestational age (r=-0.52; p<0.001) and birth weight (r=-0.37; p=0.008), but not with visual acuity (logMAR) (r=-0.10; p=0.55). Central retinal layers (ganglion cell, IPL, INL, OPL, ONL) were significantly thicker (p<0.01) in children with regressed ROP than in controls while photoreceptor layers (inner segment, outer segment+RPE) were unaffected (p=0.08).
Total thickness in the central fovea, not in the extrafovea, was significantly greater in children with regressed ROP than in full term controls. All retinal layers were thicker except photoreceptor layers. Central total thickness was associated with gestational age and birth weight. The most abnormal foveal structure was found in children born at 24-27 weeks gestation, a critical period for vascularization of the macular region.
This PDF is available to Subscribers Only