April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Role of Early Liver Function for Igf-i Synthesis and Later Rop Development
C. A. Lofqvist; G. Hellgren; A. Niklasson; E. Engstrom; A.-L. Hard; I. Hansen-Pupp; D. Ley; L. E. Smith; A. Hellstrom
Author Affiliations & Notes
  • C. A. Lofqvist
    Ophthalmology/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • G. Hellgren
    Pediatrics/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • A. Niklasson
    Pediatrics/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • E. Engstrom
    Pediatrics/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • A.-L. Hard
    Ophthalmology/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • I. Hansen-Pupp
    Pediatrics, Lund University, Gothenburg, Sweden
  • D. Ley
    Pediatrics, Lund University, Gothenburg, Sweden
  • L. E. Smith
    Ophthalmology, Harvard Univ/Childrens Hospital, Boston, Massachusetts
  • A. Hellstrom
    Ophthalmology/Sahlgrenska Academy,
    University of Gothenburg, Gothenburg, Sweden
  • Footnotes
    Commercial Relationships  C.A. Lofqvist, None; G. Hellgren, None; A. Niklasson, None; E. Engstrom, None; A.-L. Hard, None; I. Hansen-Pupp, None; D. Ley, None; L.E. Smith, None; A. Hellstrom, None.
  • Footnotes
    Support  Swedish Research Council
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5226. doi:
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      C. A. Lofqvist, G. Hellgren, A. Niklasson, E. Engstrom, A.-L. Hard, I. Hansen-Pupp, D. Ley, L. E. Smith, A. Hellstrom; The Role of Early Liver Function for Igf-i Synthesis and Later Rop Development. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5226.

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Abstract

Purpose: : AFP is a critical serum transport protein produced by the liver during embryogenesis and can be used as a marker for liver development. During development fetal AFP starts to drop in early third trimester. Insulin-like growth factors (IGFs) are mainly synthesized by more mature hepatocytes. Our previous research has established that lack of IGF-I is one of the most important factors for the development of ROP. We have shown both in mice and in children that low levels of serum IGF-I are strongly associated with reduced vessel survival. Thus, the aim of this study was to explore if poor liver development reflected in activity AFP levels was associated with, circulating IGF-I levels as well as ROP development.

Methods: : Eighty-six infants (39 boys) born at the university clinics in Gothenburg and Lund 2000-2007 with a gestational age (GA) of 26.4 weeks (range 23.0 - 29.6) and a birth weight (BW) of 857 g (range 348 -1540) were included in the present study where weekly serum samples of IGF-I from birth to 36 postmenstrual (PMA) weeks and serum AFP levels at birth were evaluated along with the development of ROP.

Results: : There was an association between AFP at birth and mean serum IGF-I at PMA 30-33 weeks (when induction of ROP occurs). A multiple regression model including AFP serum levels at birth, birth weight standard deviation score (SDS), GA and gender explained mean serum levels of IGF-I at PMA 30-33 weeks, R2=0.324, p<0.001. Preliminary multinomial logistic regression analysis suggests that there is an association for GA, BW and AFP at birth with later development of threshold ROP and that this association is stronger for girls.

Conclusions: : We found that AFP, possibly reflecting liver development, explained postnatal serum IGF-I levels. In the best fitted model explaining threshold ROP AFP was included. Thus the degree of early liver activity may be a factor responsible for later ROP development.

Keywords: retinopathy of prematurity • growth factors/growth factor receptors 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
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