April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Episcleral Unidirectional and Sustained Delivery of Celecoxib and Triamcinolone Acetonide, Transscleral Diffusion and Efficacy Testing on Matrigel-induced Models of Choroidal and Retinal Neovascularization
R. A. P. P. De Carvalho; G. G. Gum; P. P. Ko; G. Matsutani; C. Mendes; E. J. Oliveira; M. C. V. Mamani
Author Affiliations & Notes
  • R. A. P. P. De Carvalho
    3T Ophthalmics, Irvine, California
  • G. G. Gum
    Biological Test Center, Irvine, California
  • P. P. Ko
    Biological Test Center, Irvine, California
  • G. Matsutani
    3T Biopolymers, Sao Paulo, Brazil
  • C. Mendes
    3T Biopolymers, Sao Paulo, Brazil
  • E. J. Oliveira
    Farmacia, Universidade Federal da Paraiba, Joao Pessoa, Brazil
  • M. C. V. Mamani
    3T Biopolymers, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  R.A.P.P. De Carvalho, 3T Ophthalmics, F; 3T Ophthalmics, I; 3T Ophthalmics, 3T Biopolymers, E; 3T Ophthalmics, P; G.G. Gum, Biological Test Center, F; P.P. Ko, Biological Test Center, F; G. Matsutani, 3T Biopolymers, E; C. Mendes, 3T Biopolymers, E; E.J. Oliveira, None; M.C.V. Mamani, 3T Biopolymers, E.
  • Footnotes
    Support  CNPq, FAPESP
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5332. doi:
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      R. A. P. P. De Carvalho, G. G. Gum, P. P. Ko, G. Matsutani, C. Mendes, E. J. Oliveira, M. C. V. Mamani; Episcleral Unidirectional and Sustained Delivery of Celecoxib and Triamcinolone Acetonide, Transscleral Diffusion and Efficacy Testing on Matrigel-induced Models of Choroidal and Retinal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5332.

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Abstract

Purpose: : To characterize the in vitro elution, transscleral diffusion, pharmacokinetics and pharmacodynamics of celecoxib and triamcinolone acetonide (TA), formulated in sustained-release poly(lactide-co-glycolide)polymers and delivered from episcleral exoplants.

Methods: : In vitro

Results: : In vitro,

Conclusions: : In vitro

Keywords: choroid: neovascularization • sclera • drug toxicity/drug effects 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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