April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Quantitative Characteristics of Second-Order Kernel (SOK) of Multifocal Electroretinogram (mfERG) in Different Retinal Diseases
Author Affiliations & Notes
  • I. V. Glybina
    Ophthalmology, Wayne State Univ/Kresge Eye Inst, Detroit, Michigan
  • Footnotes
    Commercial Relationships  I.V. Glybina, None.
  • Footnotes
    Support  May Mitchell Royal Foundation; Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5345. doi:
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      I. V. Glybina; Quantitative Characteristics of Second-Order Kernel (SOK) of Multifocal Electroretinogram (mfERG) in Different Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5345.

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Abstract

Purpose: : To study significance of mfERG SOK in patients with different retinal diseases.

Methods: : First-order kernel (FOK) and SOK were analyzed in mfERGs recorded from: 19 patients with high myopia (HM), 17 - cone-rod dystrophy (CRD), 22 - plaquenyl toxicity (PT), 10 - non-proliferative diabetic retinopathy (NPDR), 6 - macular edema (ME), 13 - optic neuropathy (ON), 31 - early stage of age-related macular degeneration (AMD). Amplitudes and implicit times were measured and averaged across six multifocal eccentricities for the N1 and P1 components of the FOK, and for the first negative component (n1) and first positive component (p1) of the SOK. Results were compared to the mfERG normative age-matched database. All recordings and analyses were performed using VERISTM multifocal system, software version 5.1 (Redwood City, CA).

Results: : In all groups, abnormalities of the FOK were always associated with significant decrease of the n1 and p1 components of the SOK as well as delays of their implicit times. In addition, patients with regional or site-specific abnormalities of FOK (perifoveal and/or peripheral depressions in PT; areas of intraretinal hemorrhages in NPDR; foveal and/or perifoveal depressions in AMD; peripheral depressions in ON) often showed diffuse reductions and delays of the n1 and p1 components across all eccentricities, which correlated with worse visual acuity. Patients with diffuse reductions of the N1 and P1 amplitudes and large areas of N1 and P1 implicit time delays (CRD, ME, some of AMD and NPDR) showed absence of SOK predominantly within three central eccentricities and significant depressions and delays of n1 and p1 components within the rest of the tested field. HM was associated with depression of both FOK and SOK within two central and one-two peripheral-most eccentricities.

Conclusions: : SOK provides valuable information about damage to the inner retinal layers which can be helpful in interpreting central visual loss and determining prognosis of the disease.

Keywords: retina • electrophysiology: clinical • electroretinography: clinical 
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