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I. M. Zand-Hadas, E. Fernández-Muñóz, A. A. Lorenzo, A. A. Rodríguez-Reyes; Histopathological Findings of the Anterior Lens Capsule in Vitrectomized Patients With Silicone Oil Tamponade. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5389.
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To describe the histopathological changes of the anterior lens capsule (ALC) in victrectomized patients with silicone oil tamponade.
We included samples of ALC from consecutive eyes of patients with proliferative diabetic retinopathy and history of vitrectomy and silicone oil tamponade that underwent cataract surgery. The samples were formalin-fixed and paraffin embedded tissue. From each sample, 4 histological sections were obtained. All sections were stained with hematoxilyn-eosin, periodic acid Shiff and Sirius red dye and examined using light microscopy and polarized light. We evaluated capsular thickness (CT), epithelial features and the presence of different types of collagen. ALC of diabetic patients without prior vitrectomy were used as controls.
We analyzed ten samples of ALC. Two of them were from vitrectomized patients and eight from non-victrectomized patients. From the two vitrectomized samples, both had silicone oil as tamponade. CT was greater by more than 2µm in samples obtained from victrectomized patients. Hyperplasia, fibrosis and inflammatory cells were found in one of them. Type 1 and 3 collagen was not found in victrectomized samples.
A greater CT and the presence of capsule fibrosis may explain the empirical observation of a different capsular consistency during capsulorrhexis in vitrectomized patients. Contrary to our hypothesis, collagen types 1 and 3 were not found in the ALC.
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