April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Effects of Topical Coenzyme Q After Cataract Surgery. A Clinical and Confocal Study
Author Affiliations & Notes
  • P. Fogagnolo
    Fondazione GB Bietti-IRCCS, Rome, Italy
  • G. Ceresara
    University of Milan, San Paolo H, Milan, Italy
  • R. Paderni
    University of Milan, San Paolo H, Milan, Italy
  • P. Lapadula
    University of Milan, San Paolo H, Milan, Italy
  • L. Rossetti
    University of Milan, San Paolo H, Milan, Italy
  • N. Orzalesi
    University of Milan, San Paolo H, Milan, Italy
  • Footnotes
    Commercial Relationships  P. Fogagnolo, None; G. Ceresara, None; R. Paderni, None; P. Lapadula, None; L. Rossetti, None; N. Orzalesi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5422. doi:
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      P. Fogagnolo, G. Ceresara, R. Paderni, P. Lapadula, L. Rossetti, N. Orzalesi; The Effects of Topical Coenzyme Q After Cataract Surgery. A Clinical and Confocal Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5422.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the postoperative effects of topical coenzyme Q in patients who underwent cataract surgery.

Methods: : 20 consecutive patients who underwent uneventful cataract surgery (3.2-mm temporal incision, phacoemulsification + IOL in the bag) were treated with topical antibiotics and corticosteroids for 2 weeks after surgery and, thereafter, with topical coenzyme Q or saline solution twice daily for 3 months. Patients received full eye examination and the following examinations before surgery and at days 14, 90: Schirmer test (ST), Break-up time (BUT), aestesiometry (AE), in vivo confocal microscopy of the cornea. The density of the sub-basal nerves was calculated in the central (CND) and temporal (TND) cornea.

Results: : Before surgery ST was 12±3 mm, BUT 11±2 sec, AE 58±2 mm, CND 7.1±2.6, TND 6.0±2.4. At day 14, a small decrease of ST, BUT, AE was found (2±1 mm, 1±1 sec and 8±3 mm respectively; P>0.05 compared with baseline), whereas a significant reduction in CND (-2.3±2.1, P=0.003), and TND (-2.4±1.9, P=0.001) was shown. At day 90, ST, BUT, AE were similar compared with baseline (P>0.05), whereas there were higher CND (6.6±3.1) and TND (5.0±3.1) compared with day 14 (P=0.01 and 0.05 respectively).

Conclusions: : Our results confirm that even uneventful cataract surgery leads to relevant changes of the corneal nerves which may influence ocular surface function. From our short-term data, a 3-month treatment with topical coenzyme Q had a positive effect in restoring the normal anatomy of the sub-basal nerve plexus. Longer follow-up and comparison with controls are needed to provide confirmation of these findings.

Keywords: cataract 
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