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G. W. Lyles, K. L. Cohen, M. W. Aschbrenner, J. El-Khorazaty, D. Lam; Anterior Chamber Depth Measurements Following Cycloplegia Using Photographic Image Analysis (IOLMasterTM) and Anterior Segment Optical Coherence Tomography (VisanteTM) and Their Relationship to the Haigis Formula Derived Postop Anterior Chamber Depth. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5430.
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Comparison of anterior chamber depth measurements (ACD) in normal phakic eyes following cycloplegia using photographic image analysis (IOLMasterTM) and anterior segment optical coherence tomography (OCT) (VisanteTM) (Carl Zeiss Meditec, Dublin, CA) and their relationship to the Haigis formula derived anterior chamber depth.
Prospective study of 38 eyes of 23 patients with no history of eye disease. Eyes received one drop of phenylepherine (2.5%) and one drop of tropicamide (1%). Thirty minutes later, the ACD was measured with IOLMasterTM (IOLM) and OCT. OCT ACD was measured using both an automated (aOCT) and manual measurement (mOCT). aOCT is a measurement from the tear film to the anterior lens capsule; mOCT is a measurement from the corneal epithelium to the anterior lens capsule. IOLM ACD is internally recalibrated to measure from the corneal epithelium to the anterior lens capsule.
The ACD with IOLM (mean (SD)) was 3.54mm (0.35), with aOCT was 3.59mm (0.40), and with mOCT was 3.56mm (0.40). Pearson correlation coefficients were 0.9403 for aACD and IOLM and 0.9299 for mACD and IOLM. The mean difference between aOCT and IOLM was 0.0418 (p=0.07); the mean difference between mOCT and IOLM was 0.0124 (p=0.61). A Bland-Altman assessment for agreement found 95% limits of agreement of 0.309mm and -0.285mm for mACD and IOLM, and 0.322mm and -0.239mm for aACD and IOLM. Plots of mOCT and aOCT versus IOLM were created with a fitted line and compared to a one-to-one line. Calculated postop ACD (Haigis for AMO ZCB00 IOL) was (mean (SD)) 5.46mm (0.25) for IOLM and 5.47mm (0.25) for mOCT (p=0.55).
There are few studies comparing ACD measurements between the IOLMasterTM and VisanteTM, and to our knowledge no prior studies examined differences in a cycloplegic state (as recommended in the IOLMasterTM manual). Prior studies found deeper ACD measurements using VisanteTM. Our study found no differences using either mOCT or aOCT compared to IOLM. If IOLM is presumed to be the gold standard, then our results suggest that both mOCT and aOCT tended to produce lower measurements for smaller ACD and higher measurements for deeper ACD. Regardless, measuring preop ACD by either method in the cycloplegic state did not make any difference in the calculated postop ACD using the Haigis formula.
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