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F. C. Gundogan, O. Oz, S. Demirkaya, G. Sobaci; Color Vision Testing versus Pattern Visual Evoked Potentials in Multiple Sclerosis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5471.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the sensitivities of color vision testing and pattern visual evoked potentials (PVEP) in the diagnosis of optic pathway involvement in multiple sclerosis (MS) patients without a history of visual symptoms.
The right eyes of 20 MS patients and 20 control subjects were included. Color vision was evaluated by Farnsworth-Munsell (FM) 100 Hue test. Total error scores (TES) in FM-100 Hue test were assessed. PVEP recordings were peformed by Roland-Consult Retiscan system. A checkerboard pattern with 1 degree check size was used. The contrast between black and white squares was 99%.
The normative data for FM-100 Hue test and PVEP test were assessed by 95% confidence interval for P100 latency and TES in FM-100 Hue test in the control subjects. Five percent confidence interval level were used as normative data for P100 amplitude. With respect to the normative datas, 14 MS patients (70%) had increased TES in FM-100 Hue test, 11 (55%) had delayed P100 latency. Nine MS patients (45%) had decreased P100 amplitude. Areas under the ROC curve were 0.944 for FM-100 Hue test, 0.753 for P100 latency and 0.173 for P100 amplitude (Figure 1).
FM 100 Hue color vision testing is superior to PVEP in detecting visual pathway involvement in MS.
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