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A. Kamei, E. Nagasaka; Multifocal Photopic Negative Response (mfPhNR) and Retinal Nerve Fiber Layer Thickness (RNFLT) in Patients with Optic Nerve Lesions. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5473.
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To evaluate the interrelation of mfPhNR and RNFLT in the superior and inferior region in patients with optic nerve lesions.
Twelve eyes of twelve volunteers with normal vision and twenty eyes of ten patients with optic nerve lesions including normal tension glaucoma (NTG) were tested.The mfPhNR was recorded with the VERIS Science System 5.0.4. The visual stimulus was made up of 37 hexagons in an approximately 40-degree visual field, Pseudo-randomly alternating between black (5cd/m2) and white (200cd/m2) on the CRT monitor. Burian-Allen ERG Electrodes, Adult-bipolar or Pediatric-bipolar, were used for this testing. The recording time was approximately 8 min. with dilated pupils having the best-corrected visual acuity. The band pass filter of the amplifier was set from 1 to 100 Hz. The amplification and stimulus frequency were set to 10000 and 9.41 Hz (8 frames) respectively.Each trace of the mfPhNR found in all the superior and inferior regions was analyzed.RNFLT was measured using Cirrus HD-OCT. The average RNFLT in all superior and inferior quadrants was applied for analysis.
There was a correlation between the amplitude of the mfPhNR in the superior region and RNFLT in the inferior quadrant (R=0.6365, P=0.000394). There was also a correlation between the amplitude of the mfPhNR in the inferior region and RNFLT in the superior quadrant (R=0.5743, P=0.001385).
We presented previously that the amplitude of mfPhNR decreased beyond in visual field defect area in patients, even in less affected eyes with NTG as same as in more affected eyes with NTG.It may be possible that mfPhNR detect preperimetric optic neuropathy which shows decrease of RNFLT without visual field defect.
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