April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Perimetry Instrument Comparison Study: Comparing the Diagnostic Performance of Four Threshold Perimetry Tests to Discriminate Between Healthy and ‘Glaucomatous’ Eyes (Interim Analysis)
Author Affiliations & Notes
  • D. Sinapis
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • A. Sinapis
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • C. Bergin
    Optometry and Visual Sciences, City University, London, United Kingdom
  • R. Moosavi
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • R. A. Russell
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • G. M. Verdon-Roe
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • C. Balian
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
  • J. Flanagan
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • D. P. Crabb
    Optometry and Visual Sciences, City University, London, United Kingdom
  • D. F. Garway-Heath
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    Bietti Foundation, Rome, Italy
  • Footnotes
    Commercial Relationships  D. Sinapis, None; A. Sinapis, None; C. Bergin, Moorfields MDT, P; R. Moosavi, Pfizer, F; R.A. Russell, None; G.M. Verdon-Roe, Pfizer, F; Moorfields MDT, P; C. Balian, None; J. Flanagan, Heidelberg Engineering, F; Optovue Inc., F; Heidelberg Engineering, C; Heidelberg Engineering, R; D.P. Crabb, Moorfields MDT, P; D.F. Garway-Heath, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Moorfields MDT, P; Carl Zeiss Meditec, R.
  • Footnotes
    Support  Unrestricted research support from Pfizer
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5504. doi:https://doi.org/
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      D. Sinapis, A. Sinapis, C. Bergin, R. Moosavi, R. A. Russell, G. M. Verdon-Roe, C. Balian, J. Flanagan, D. P. Crabb, D. F. Garway-Heath; Perimetry Instrument Comparison Study: Comparing the Diagnostic Performance of Four Threshold Perimetry Tests to Discriminate Between Healthy and ‘Glaucomatous’ Eyes (Interim Analysis). Invest. Ophthalmol. Vis. Sci. 2010;51(13):5504. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To consider interim results of the relative diagnostic performance of four threshold tests to discriminate between healthy and ‘glaucomatous’ eyes, defined by neuroretinal rim loss and intraocular pressure (IOP) level.

Methods: : One hundred and thirty-six from a planned 320 participants have been recruited and tested in a four centre study of perimetry instruments (mean age=58, range 18 to 83 years). Patient selection criteria were: (i) Heidelberg Retina Tomograph (HRT) Moorfields Regression Analysis (MRA) ‘Outside Normal Limits’; rim area >0.5mm2 and (ii) IOP >21mmHg at referral; <26mmHg at time of testing. Healthy subjects had HRT MRA ‘Within Normal Limits’ and IOP ≤21mmHg. Thus, the reference standard for ‘glaucoma’ was independent of perimetry. One eye of each subject was tested on Standard Automated Perimetry (SAP, 24-2 SITA standard), Frequency Doubling Technology Perimetry (FDT, 24-2 ZEST), Heidelberg Edge Perimetry (HEP, 24-2 ASTA standard) and the Moorfields Motion Displacement Test (MDT, WEBS); order randomized and unreliable tests (false positive rate >15%) were repeated once. Sensitivity and specificity for different numbers of significantly depressed points (P <5%) were recorded. The areas under the receiver operating characteristic curves (AUC) were computed.

Results: : At approximately 95% specificity, the sensitivities were: SAP 32% (95% confidence interval [CI]: 23 to 43%); HEP 38% (95% CI: 28 to 49%); FDT 46% (95% CI: 35 to 56%); MDT 32% (95% CI: 23 to 43%). The AUCs were: SAP 73% (95% CI: 68 to 78%); HEP 79% (95% CI: 74 to 84%); FDT 77% (95% CI: 72 to 82%); MDT 72% (95% CI: 66 to 77%).

Conclusions: : The diagnostic performance of each of the four tests was similar in this group with very early glaucoma.Acknowledgement of collaborators: L.Tanga, M.Michelessi, F.Oddone (Bietti Foundation, Rome, Italy), G.Sharpe, P.Artes (Dalhousie University, Halifax, NS, Canada).

Keywords: visual fields 
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