April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Center-Surround Interactions in Flicker Perception of Glaucoma Patients
Author Affiliations & Notes
  • C. E. Teixeira
    Biological Sciences Institute, Universidade Federal do Para, Belem, Brazil
  • L. C. L. Silveira
    Biological Sciences Institute, Universidade Federal do Para, Belem, Brazil
  • J. Kremers
    Dept of Ophthalmology, University of Erlangen, Erlangen, Germany
  • Footnotes
    Commercial Relationships  C.E. Teixeira, None; L.C.L. Silveira, None; J. Kremers, None.
  • Footnotes
    Support  CAPES (Brazil) and DAAD (Germany)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5515. doi:
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    • Get Citation

      C. E. Teixeira, L. C. L. Silveira, J. Kremers; Center-Surround Interactions in Flicker Perception of Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5515.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate lateral interactions in flicker perception of glaucoma patients using psychophysical methods.

Methods: : Subjects matched the perceived flicker strength in a center of a reference stimulus surrounded by a simultaneously flickering annulus (50% Michelson contrast in both stimuli) by adjusting the modulation depth in a test stimulus physically identical to this center stimulus but without the annulus. Using LCD goggles synchronized to the frame rate of a CRT screen, the center and annulus could be presented monoptically or dichoptically. In the monoptic condition, center-surround interactions can have a subcortical and cortical origin. In the dichoptic condition, center-surround interactions cannot occur in the retina and the LGN and therefore isolates the cortical component. Participants were age-matched control subjects (n=7) and pre-perimetric (n=12) and perimetric (n=4) patients. Paired t test was used in statistical analysis.

Results: : The perceived flicker strength was larger when the center and annulus stimuli modulated in counterphase than when modulated in-phase. In addition, this center-surround interaction was larger in the monoptic condition. A significant difference between control subjects and perimetric patients data was found in counter-phase dichoptic condition (P=0,0402). Although no statistical difference was found between control subjects and pre-perimetric patients data (P>0.05), some pre-perimetric patients showed clearly altered perceived flicker strengths.

Conclusions: : The evaluation of center-surround interactions in flicker perception can potentially reveal glaucomatous changes in subcortical and cortical mechanisms.

Keywords: visual impairment: neuro-ophthalmological disease • visual fields • temporal vision 

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