April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Long-Term Follow-Up of Preperimetric Open-Angle Glaucoma: Improvement of the Visual Field in Morphological Stable Patients Only
Author Affiliations & Notes
  • A. G. Junemann
    Ophthalmology, Ophthalmology,
    University of Erlangen Nurnberg, Erlangen, Germany
  • N. Bellios
    Ophthalmology, Ophthalmology,
    University of Erlangen, Erlangen, Germany
  • R. Laemmer
    Ophthalmology, University of Erlangen-Nuremberg, Erlangen, Germany
  • B. Link
    Ophthalmology, Ophthalmology,
    University of Erlangen Nurnberg, Erlangen, Germany
  • C. Y. Mardin
    Ophthalmology, University Erlangen-Nurnberg, Erlangen, Germany
  • J. Kremers
    Department of Ophthalmology, Dept of Ophthalmology,
    University of Erlangen, Erlangen, Germany
  • F. E. Kruse
    Department of Ophthalmology, Dept of Ophthalmology,
    University of Erlangen Nurnberg, Erlangen, Germany
  • F. K. Horn
    Ophthalmology, Ophthalmology,
    University of Erlangen Nurnberg, Erlangen, Germany
  • Footnotes
    Commercial Relationships  A.G. Junemann, None; N. Bellios, None; R. Laemmer, None; B. Link, None; C.Y. Mardin, None; J. Kremers, None; F.E. Kruse, None; F.K. Horn, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5517. doi:
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    • Get Citation

      A. G. Junemann, N. Bellios, R. Laemmer, B. Link, C. Y. Mardin, J. Kremers, F. E. Kruse, F. K. Horn; Long-Term Follow-Up of Preperimetric Open-Angle Glaucoma: Improvement of the Visual Field in Morphological Stable Patients Only. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5517.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate visual field changes in patients with preperimetric open-angle glaucoma (preOAG) with and without morphological progression.

Methods: : 159 patients with preperimetric open-angle glaucoma of the Erlangen Glaucoma Registry with a follow-up of at least 6 years (mean follow-up 8.45±2.3 years) were included in this study (55.6±10.6 years, 71 female, 88 male). Examinations were performed yearly. The visual field was analysed in a morphological stable (s-group) and progressive group (p-group). The morphological progression was defined using color stereo photographs of the optic disk. Progression criteria included reduction of neuroretinal rim, occurrence of notches, and hemorrhages. The mean defect (MD, Octopus 500, G1 program) as a global parameter was used for visual field analysis. In addition, the baseline data of age, maximal intraocular pressure, neuroretinal rim area, central corneal thickness, value of lens opacity meter for cataract formation were analysed. Non-parametric testing (Mann-Whitney U, Friedman) was performed.

Results: : Morphological progression was found in 62 patients (39%). The MD showed no significant difference between both groups at every examination time point (Mann-Whitney, p>0.5), including baseline. The s-group showed a significant improvement of MD between baseline (0.765±1.1dB) and endpoint (-0.45±1.5dB, Friedman, p<0.05). The p-group showed no significant difference (0.755±0.94dB, 0.975±1.5dB, p>0.1). There was no significant difference for age, maximal IOP, neuroretinal rim area, central corneal thickness, and lens opacity meter between both groups at baseline (p>0.5).

Conclusions: : This study suggest that a stable MD might not to be sufficient to define a stable visual field in longitudinal studies. The lack of long-time learning effect in patients with morphological progression may indicate a deterioration of the visual field.

Clinical Trial: : www.clinicaltrials.gov nct00494923

Keywords: visual fields 
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