Purchase this article with an account.
S. Demirel, C. G. de Moraes, S. K. Gardiner, J. M. Liebmann, G. A. Cioffi, R. Ritch, M. O. Gordon, M. A. Kass, Ocular Hypertension Treatment Study; Rates of Change of Mean Deviation in the Ocular Hypertension Treatment Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5520.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To assess the rates of change of visual field mean deviation (MD) in OHTS, overall, among eyes developing POAG and by how POAG was determined.
The analysis dataset included eyes with ≥ 10 reliable visual fields (VF) covering ≥ 5 years; 2865 eyes from 1438 participants met these criteria. The rate of change of MD over time [MDR (dB/Yr)] was calculated for each eye using linear regression. Differences in MDR by POAG outcome and whether a POAG endpoint was detected for VF, optic disc or both VF and optic disc were tested using general estimating equations that took account of correlations between eyes of individuals.
The MDRs for different categories of eyes are shown below. The average MDR was significantly worse than zero for all eyes and for non-POAG eyes separately (both p < 0.001). POAG eyes had significantly worse MDRs than non-POAG eyes (C vs. B, p < 0.001). VF endpoint only eyes had significantly worse MDRs than non-POAG eyes (D vs. B, p < 0.001), as did optic disc endpoint only eyes (E vs. B, p = 0.024). Eyes that reached an optic disc and VF endpoint, not necessarily concurrently, deteriorated fastest, and significantly faster than VF endpoint only eyes (F vs. D, p = 0.004).
Our analyses show that non-POAG ocular hypertensive eyes deteriorate significantly faster than established normative rates. Eyes that develop POAG show significantly worse MDRs than non-POAG eyes, regardless of endpoint type. Eyes that reach both an optic disc endpoint and a VF endpoint at any time during follow up had significantly worse MDRs than eyes that only reached a VF endpoint.
This PDF is available to Subscribers Only