April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Association Between Increased Lens Vault and Angle Closure in Chinese Singaporeans
M. E. Nongpiur; M.-G. He; N. Amerasinghe; L. M. Sakata; D. S. Friedman; W.-T. Tay; S. D. Smith; T.-Y. Wong; T. Aung
Author Affiliations & Notes
  • M. E. Nongpiur
    Glaucoma,
    Singapore Eye Research Institute, Singapore, Singapore
  • M.-G. He
    Glaucoma, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China
  • N. Amerasinghe
    Glaucoma,
    Singapore Eye Research Institute, Singapore, Singapore
  • L. M. Sakata
    Glaucoma, Universidade Federal do Parana, Curitiba, Brazil
  • D. S. Friedman
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • W.-T. Tay
    Glaucoma,
    Singapore Eye Research Institute, Singapore, Singapore
  • S. D. Smith
    Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, New York, New York
  • T.-Y. Wong
    Ophthalmology,
    Singapore Eye Research Institute, Singapore, Singapore
  • T. Aung
    Glaucoma,
    Singapore Eye Research Institute, Singapore, Singapore
  • Footnotes
    Commercial Relationships  M.E. Nongpiur, None; M.-G. He, None; N. Amerasinghe, None; L.M. Sakata, None; D.S. Friedman, None; W.-T. Tay, None; S.D. Smith, None; T.-Y. Wong, None; T. Aung, Carl Zeiss Meditec, F; Carl Zeiss Meditec, R.
  • Footnotes
    Support  BioMedical Research Council and National Medical Research Council, Singapore
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5534. doi:
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      M. E. Nongpiur, M.-G. He, N. Amerasinghe, L. M. Sakata, D. S. Friedman, W.-T. Tay, S. D. Smith, T.-Y. Wong, T. Aung; Association Between Increased Lens Vault and Angle Closure in Chinese Singaporeans. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5534.

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Abstract

Purpose: : To investigate the relationship between lens vault and angle closure in Chinese Singaporeans.

Methods: : This comparative study examined 102 Chinese subjects with angle closure (consisting of primary angle closure [PAC] and primary angle closure glaucoma [PACG]) attending a glaucoma clinic; and 176 Chinese subjects with open angles and no evidence of glaucoma recruited from an ongoing population-based cross-sectional study. PAC was defined as the presence of appositional angle closure for ≥180 degrees with peripheral anterior synechiae and/ or raised intraocular pressure; PACG was defined as eyes with PAC associated with glaucomatous optic neuropathy. All participants underwent gonioscopy, A-scan biometry, and anterior-segment OCT (ASOCT, Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure Lens Vault (LV) on horizontal ASOCT scans. LV was defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the two scleral spurs. A-scan results were used to calculate Lens Position (LP - defined as anterior chamber depth [ACD] +1/2 lens thickness [LT]), and Relative LP (RLP - defined as LP/axial length [AL]).

Results: : Significant differences between normal and angle closure eyes were found for LV (315.5±271.8 vs 901.3±264.8µm, p=<0.001), LT (3.90±0.73 vs 4.20±0.92mm, p=0.01), ACD (2.95±0.37 vs 2.66±0.37mm, p<0.001) and AL (23.92±1.37 vs 22.86±0.93mm, p<0.001), but no significant differences were found for LP (4.90±0.54 vs 4.76±0.51mm, p=0.34) or RLP (0.20±0.02 vs 0.21±0.02, p=0.14). After adjusting for age, gender, ACD, LT and RLP, increased LV was significantly associated with angle closure (odds ratio [OR] 48.1, 95% confidence interval [CI] 12.8-181.3 - comparing lowest quartile to the highest quartile). There was no significant association of LV with RLP or LT.

Conclusions: : Increased LV is independently associated with angle closure in Chinese Singaporeans.

Keywords: anterior segment • imaging/image analysis: clinical 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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