April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Relationship of Anterior Chamber Angle Width and Intraocular Pressure in a Community-Based Study in Singapore
Author Affiliations & Notes
  • L. M. Sakata
    Glaucoma, Universidade Federal do Parana, Curitiba, Brazil
    Singapore National Eye Centre, Singapore, Singapore
  • R. Lavanya
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Reserch Institute, Singapore, Singapore
  • M.-G. He
    State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China
  • Y.-H. Chan
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • T. Aung
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Footnotes
    Commercial Relationships  L.M. Sakata, None; R. Lavanya, None; M.-G. He, None; Y.-H. Chan, None; T. Aung, Carl-Zeiss Meditec, F.
  • Footnotes
    Support  Grants from Singhealth, Singapore, National Medical Research Council, Singapore and the National Research Foundation, Singapore
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5545. doi:
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      L. M. Sakata, R. Lavanya, M.-G. He, Y.-H. Chan, T. Aung; Relationship of Anterior Chamber Angle Width and Intraocular Pressure in a Community-Based Study in Singapore. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5545.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To assess the relationship between intra-ocular pressure (IOP) and anterior chamber angle (ACA) width assessed by gonioscopy and anterior-segment OCT (AS-OCT, Carl Zeiss Meditec, Dublin, CA) in a Singapore population.

Methods: : 2047 subjects aged 50-years and over without ophthalmic symptoms recruited from a community polyclinic underwent gonioscopy, Goldmann applanation tonometry, and AS-OCT. On gonioscopy, a quadrant was considered to be closed if the posterior trabecular meshwork was not visible on non-indentation gonioscopy. On AS-OCT, a fellowship trained glaucoma specialist graded images obtained at the four quadrants of the eye as having an open or closed ACA (qualitative analysis). In the AS-OCT quantitative analysis, the anterior chamber depth (ACD), anterior chamber volume (ACV), angle opening distance (AOD) and trabecular-iris space area (TISA) 750 um from the scleral spur were measured using a customized computer software (Zhongshan Angle Assessment Program, Guangzhou, China). IOP values were adjusted for age, gender, diabetes, systemic hypertension, central corneal thickness, and body mass index.

Results: : Mean IOP was 14.7 mmHg (SD±2.4) (range 8-26). IOP [mean±SE] increased according to the number of quadrants closed on gonioscopy (none-14.6±0.1, one-14.8±0.2, two-15.1±0.3, three-15.0±0.2, four-15.7±0.2mmHg), and according to the number of quadrants considered closed on AS-OCT (none-14.6±0.1, one-14.9±0.1, two-14.7±0.1, three-15.0±0.2, four- 15.9±0.2mmHg). The quantitative ACA analysis excluded 587 eyes, mostly due to inability to locate the scleral spur. The IOP was significantly higher comparing the 1st vs. 4th quartile of ACD (15.3±0.1 vs. 14.4±0.1mmHg, p<0.001), ACV (15.1±0.1 vs. 14.5±0.1mmHg, p<.001), AOD750micra (15.2±0.1 vs. 14.4±0.1mmHg, p<.001), TISA750 (15.2±0.1 vs. 14.4±0.1mmHg, p<.001).

Conclusions: : IOP tended to increase according to the number of ACA quadrants considered closed on gonioscopy and AS-OCT. IOP also increased in eyes with narrower ACA as assessed quantitatively by AS-OCT. These data suggest that the degree of ACA opening influences IOP level.

Keywords: intraocular pressure • imaging/image analysis: clinical 

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