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T. Usui, S. Yokoo, S. Amano, Y. Oike; Roles of Angiopoietin Like Protein-2 in Corneal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5704.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the roles of angiopoietin like protein 2 (Angptl2) in corneal neovascularization using transgenic mice expressing Angptl2 driven by cytokeratin 14 (K14, K14-Angptl2 mice).
Corneal neovascularization was induced by suturing 10-0 nylon 1 mm away from limbal vessel in K14-Angptl2 mice and control mice (Balb/C). Five days after suturing neovascularized area was determined by endothelial specific Isolectin B4 staining. Macrophage infiltration as inflammatory responses was also investigated by F4/80 immunohistochemistry and real time RT-PCR.
K14-Angptl2 mice developed the earlier angiogenic and inflammatory reactions than control mice.
Angptl2 may play important roles in corneal neovascularization as pro angiogenic and proinflammatory factors.
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