April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Roles of Angiopoietin Like Protein-2 in Corneal Neovascularization
Author Affiliations & Notes
  • T. Usui
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • S. Yokoo
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • S. Amano
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • Y. Oike
    Molecular Genetics, University of Kumamoto, Kumamoto, Japan
  • Footnotes
    Commercial Relationships  T. Usui, None; S. Yokoo, None; S. Amano, None; Y. Oike, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5704. doi:
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    • Get Citation

      T. Usui, S. Yokoo, S. Amano, Y. Oike; Roles of Angiopoietin Like Protein-2 in Corneal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5704.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the roles of angiopoietin like protein 2 (Angptl2) in corneal neovascularization using transgenic mice expressing Angptl2 driven by cytokeratin 14 (K14, K14-Angptl2 mice).

Methods: : Corneal neovascularization was induced by suturing 10-0 nylon 1 mm away from limbal vessel in K14-Angptl2 mice and control mice (Balb/C). Five days after suturing neovascularized area was determined by endothelial specific Isolectin B4 staining. Macrophage infiltration as inflammatory responses was also investigated by F4/80 immunohistochemistry and real time RT-PCR.

Results: : K14-Angptl2 mice developed the earlier angiogenic and inflammatory reactions than control mice.

Conclusions: : Angptl2 may play important roles in corneal neovascularization as pro angiogenic and proinflammatory factors.

Keywords: cornea: basic science • neovascularization • inflammation 
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