April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Pachymetric Mapping Repeatability Using Fourier-Domain Optical Coherence Tomography in Corneal Opacities
Author Affiliations & Notes
  • N. M. Samy El Gendy
    Ophthalmology, University of Southern California, Los Angeles, California
    Ophthalmology, Cairo University, Cairo, Egypt
  • Y. Li
    Ophthalmology, University of Southern California, Los Angeles, California
  • D. Huang
    Ophthalmology, University of Southern California, Los Angeles, California
  • X. Zhang
    Ophthalmology, University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships  N.M. Samy El Gendy, None; Y. Li, Optovue, Inc., Fremont, CA, F; Optovue, Inc., Fremont, CA, R, F; Optovue, Inc., Fremont, CA, R; D. Huang, Optovue, Inc., F; Optovue, Inc., I; Optovue, Inc, C; Carl Zeiss,Optovue, Inc., P; Optovue, Inc, R; X. Zhang, None.
  • Footnotes
    Support  NIH grants R01 EY018184,Charles C. Manger III, MD Chair in Corneal Laser Surgery ; Research to Prevent Blindness; Optovue, Inc. doheny core grant NIH P30 EY03040
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5816. doi:
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    • Get Citation

      N. M. Samy El Gendy, Y. Li, D. Huang, X. Zhang; Pachymetric Mapping Repeatability Using Fourier-Domain Optical Coherence Tomography in Corneal Opacities. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5816.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate the repeatability of Fourier-domain optical coherence tomography (FD-OCT) pachymetric mapping in patients with corneal scars or dystrophy

 
Methods:
 

A FD-OCT system (RTVue by Optovue, Inc.) was used to map the corneal thickness of 16 eyes of 12 patients with corneal opacity. Six eyes had corneal dystrophy (2 Reis-Buckler,4 granular dystrophy) The remaining 10 eyes had corneal scars due to various causes. The central 6 mm diameter was mapped. The repeatability was measured using pooled standard deviation (PSD) of repeat measurements. A slit-scanning tomography device (Orbscan II by Bausch & Lomb, Inc.) provided pachymetric mapping comparison.

 
Results:
 

Statistical analysis showed that repeatability of OCT pachymetric mapping was excellent in terms of pooled SD in both scar and dystrophy groups (Table).Table. Optical Coherence Tomography Pachymetry Statistics by Region.The repeatability could also be expressed as coefficient of variation, which range from 0.2% to 0.4% . Compared to OCT (536 +/- 89 µm), Orbscan II significantly under-estimated central corneal thickness (433 +/- 111 µm). The difference was statistically significant (p = 0.002).

 
Conclusions:
 

Pachymetric mapping with FD-OCT was highly repeatable even in the presence of opaque areas due to either corneal dystrophies or scars. In comparison, Orbscan II significantly under-estimated corneal thickness in the presence of opacities.  

 
Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • keratitis 
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