April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Serum Lipids and Glycated Haemoglobin Are Associated With Intraocular Pressure in European People - Epic-Eyes Study
Author Affiliations & Notes
  • P. J. Foster
    Epidemiology,
    Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom
  • D. C. Broadway
    Ophthalmology, Norfolk & Norwich Univ Hospital, Norwich, United Kingdom
  • J. L. Y. Yip
    Epidemiology,
    Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom
    Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom
  • S. Hayat
    Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom
  • R. Luben
    Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom
  • N. Dalzell
    Diabetes Research Unit, Norwich Community Hospital, Norwich, United Kingdom
  • D. F. Garway-Heath
    Glaucoma,
    Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom
  • N. J. Wareham
    MRC Epidemiology Unit, Institute of Molecular Science, Addenbrookes Hospital, Cambridge, United Kingdom
  • K.-T. Khaw
    Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom
  • Footnotes
    Commercial Relationships  P.J. Foster, None; D.C. Broadway, None; J.L.Y. Yip, None; S. Hayat, None; R. Luben, None; N. Dalzell, None; D.F. Garway-Heath, None; N.J. Wareham, None; K.-T. Khaw, None.
  • Footnotes
    Support  Research into Aging (UK), Medical Research Council (UK) NIHR Biomedical Research Centre for Ophthalmology (UK)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5829. doi:
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      P. J. Foster, D. C. Broadway, J. L. Y. Yip, S. Hayat, R. Luben, N. Dalzell, D. F. Garway-Heath, N. J. Wareham, K.-T. Khaw; Serum Lipids and Glycated Haemoglobin Are Associated With Intraocular Pressure in European People - Epic-Eyes Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5829.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the cross-sectional association between cardiovascular disease biomarkers and ocular pressure (IOP) in a UK population.

Methods: : Participants in the EPIC-Norfolk cohort were reexamined 2005-09. Three IOP measurements were obtained from each eye using the Reichert Ocular Response Analyzer. Mean Goldmann correlated IOP (IOPg) from one eye was used in the analysis. Blood pressure (BP) was recorded as the mean of two measurements taken with a sphygmomanometer. Serum lipids (HDL, LDL, trigylcerides) and glycated hemoglobin (HbA1c) were measured. Ocular axial length (AL) and AC depth (ACD) were measured using a Zeiss IOLMaster. Associations were examined using linear regression, with significance set at P<0.05.

Results: : Full IOP, HbA1c and lipid data were available on 3,750 people (2114 women) aged 49 to 91 years. Mean IOP was 16.2 (SD 3.7) mmHg. Mean for HbA1c was 5.8 (0.61)% and for low density lipoprotein (LDL) 3.16 (0.98) mmol/L. In univariate linear regression, higher systolic BP (sBP), higher diastolic BP (dBP), higher HDL and higher LDL, longer axial length and more myopic refraction were all associated with higher IOP. Higher HbA1c was of borderline significance (P=0.077). IOP was not significantly related to age, sex, serum triglycerides or ACD. In a multiple regression model, higher sBP, longer AL, higher LDL, higher HbA1c were all significantly associated with higher IOP. Age, sex, HDL, myopic refraction and dBP were not associated with IOP in this model.

Conclusions: : Higher LDL and glycated haemoglobin are associated with higher IOP in this population independent of age, sex and blood pressure.

Keywords: intraocular pressure • clinical (human) or epidemiologic studies: risk factor assessment • lipids 
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