Abstract
Purpose: :
To analyze the correlation between posterior uveitis scores and structural and functional alterations of macula.
Methods: :
19 eyes of 12 male patients were included in this study. The correlations between posterior uveitis score (PUS), best corrected visual acuity (BCVA), central foveal thickness (CFT) in optical cohorence tomography (OCT) and central mfERG responses (P1 amplitude and implicit time of first waveform) were evaluated. For statistical analysis CFT and mfERG responses of 15 eyes of 15 normal males were the referance , concordant in age and sex.
Results: :
The median age of uveitis group was 21 (range, 20-68 years) and mean follow-up was 6 months (range,1-21 months). There was unilateral uveitis in 5 patients and bilateral uveitis in 7 patients. 3 patients were diagnosed as idiopathic panuveitis and 9 patients diagnosed as Behçet panuveitis. BCVA was between 0.016-1.0 (median:0.6). The mean PUS of 19 uveitic eyes was 8.7 (range, 4-13). CFT was between 174-223 µ (median:197) in control group and between 139-870 µ (median:296) in uveitis group (p:0.001). P1 amplitudes were recorded as 59.10-193.50 nv/deg2 (median:130) in control group and 23.30-163.60 nv/deg2 (median:67.15) in uveitis group. P1 implicit times were recorded as 32.30-45.20 ms (median:39.20) in control group and 31.90-49.80 ms (median:39.80) in uveitis group. Although there was a significant difference of P1 amplitudes between control group and uveitis group (p:0.003), there was not a significant difference of P1 implicit times (p>0.05). The correlations between P1 amplitudes and implicit times, CFT, BCVA and PUS were analyzed with Pearson correlation analysis in uveitis group. There was a positive correlation between PUS and CFT (r:0.459, p:0.048), but there was a negative correlation between PUS and BCVA (r:-0.600, p:0.007). We did not found a correlation between PUS and mfERG responses. Also there was a positive correlation between BCVA and P1 amplitudes (r:0.599, p:0.009).
Conclusions: :
OCT and BCVA are more effective than mfERG test when evaluating macular functions in uveitic eyes.
Keywords: uveitis-clinical/animal model • macula/fovea • electrophysiology: clinical