April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Ocular Toxoplasmosis Recurrences: A Single Center Experience
Author Affiliations & Notes
  • U. Serra
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
    Università di Pavia, Pavia, Italy
  • K. Julian
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • C. Aknin
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • N. Cassoux
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • C. Fardeau
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • L. Paris
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • P. LeHoang
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • B. Bodaghi
    Ophthalmology, Hopital Pitie-Salpetriere, Paris, France
  • Footnotes
    Commercial Relationships  U. Serra, None; K. Julian, None; C. Aknin, None; N. Cassoux, None; C. Fardeau, None; L. Paris, None; P. LeHoang, None; B. Bodaghi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5878. doi:
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      U. Serra, K. Julian, C. Aknin, N. Cassoux, C. Fardeau, L. Paris, P. LeHoang, B. Bodaghi; Ocular Toxoplasmosis Recurrences: A Single Center Experience. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5878.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : to describe recurrence patterns in a cohort of patients with aqueous humor proven ocular toxoplasmosis, followed during 3 years, at a single referral center.Patients and

Methods: : retrospective, observational, non comparative case series including 43 patients who suffered from an active episode of toxoplasmic retinochoroiditis during 2005, confirmed by aqueous humour polymerase chain reaction (PCR) and Goldmann-Witmer coefficient positivity and managed at the Ophthalmology Department. Clinical files were analyzed in terms of signs of intraocular inflammation, number, size and location of retinochoroidal active lesions and scars, presence of ocular complications related to toxoplasmic retinochoroiditis, angiographic and visual field findings and therapeutic management.

Results: : 20 males and 23 females (mean age 37 years) were followed after an episode of toxoplasmic retinochoroiditis confirmed by analysis of ocular fluids. Five of them were immunocompromised and twelve have already experienced at least a previous episode of active toxoplasmic retinochoroiditis. Recurrences occurred in 13 patients (28%) with a mean age of 48 years. These episodes were noted during the first year of follow-up, between 12 and 24 months and between 24 and 36 months in 4, 5 and 3 patients respectively.

Conclusions: : Recurrence risk seems to increase with age (p=0.01). Recurrences seem to be more frequent if they occur during the first year after the initial episode of retinochoroiditis, especially in older patients. A prospective study is needed in order to confirm these preliminary results.

Keywords: toxoplasmosis • antibiotics/antifungals/antiparasitics • uvea 
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