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U. Serra, K. Julian, C. Aknin, N. Cassoux, C. Fardeau, L. Paris, P. LeHoang, B. Bodaghi; Ocular Toxoplasmosis Recurrences: A Single Center Experience. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5878.
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to describe recurrence patterns in a cohort of patients with aqueous humor proven ocular toxoplasmosis, followed during 3 years, at a single referral center.Patients and
retrospective, observational, non comparative case series including 43 patients who suffered from an active episode of toxoplasmic retinochoroiditis during 2005, confirmed by aqueous humour polymerase chain reaction (PCR) and Goldmann-Witmer coefficient positivity and managed at the Ophthalmology Department. Clinical files were analyzed in terms of signs of intraocular inflammation, number, size and location of retinochoroidal active lesions and scars, presence of ocular complications related to toxoplasmic retinochoroiditis, angiographic and visual field findings and therapeutic management.
20 males and 23 females (mean age 37 years) were followed after an episode of toxoplasmic retinochoroiditis confirmed by analysis of ocular fluids. Five of them were immunocompromised and twelve have already experienced at least a previous episode of active toxoplasmic retinochoroiditis. Recurrences occurred in 13 patients (28%) with a mean age of 48 years. These episodes were noted during the first year of follow-up, between 12 and 24 months and between 24 and 36 months in 4, 5 and 3 patients respectively.
Recurrence risk seems to increase with age (p=0.01). Recurrences seem to be more frequent if they occur during the first year after the initial episode of retinochoroiditis, especially in older patients. A prospective study is needed in order to confirm these preliminary results.
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