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F. T. Gaspar, M. K. Oyamada, C. E. Hirata, E. Olivalves, W. Y. Takahashi, R. A. Costa, J. H. Yamamoto; Association Between Morphological and Functional Macular Evaluations With Visual Acuity in Patients With Late-Stage Vogt-Koyanagi-Harada Disease. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5881.
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To correlate morphological and functional strategies of macular evaluation with best-corrected visual acuity (BCVA) in patients with late-stage Vogt-Koyanagi-Harada (VKH) disease.
Transversal study including 51 eyes of 29 patients in the late-stage of VKH disease at a tertiary ophthalmic referral center in Brazil. Patients underwent standardized ophthalmic evaluation, spectral optical coherence tomography (SOCT) and multifocal electroretinogram (mf-ERG). The correlation between BCVA and the integrity of reflective layers corresponding to photoreceptors’ inner and outer segments junction (macular-IS/OS) on SOCT, and between BCVA and the combination of the N1 and P1 waves’ amplitudes on mf-ERG were evaluated.
Macular-IS/OS was subdivided into preserved (>75%) (IS/OS+, 22/37;59%) and not preserved (IS/OS-, 15/37;41% ) groups. Median logMAR BCVA was influenced by the status of macular-IS/OS integrity, with better BCVA observed in those eyes presenting an overall preserved macular-IS/OS on SOCT (BCVA = 0.0 [20/20] versus BCVA = 0.7 [20/100] in eyes with <75%; p<0.001). Median logMAR BCVA was also influenced by mf-ERG results, with better BCVA observed in those eyes presenting mild (20/50; 40%) changes on mf-ERG (BCVA = 0.0 [20/20] versus BCVA = 0.2 [20/32] in eyes with severe [30/50; 60%] changes; p<0.001). The degree of concordance between morphological (SOCT) and functional (mf-ERG) macular assessments was moderate (K=0.47).
Overall macular integrity of the reflective layer corresponding to IS/OS junction evaluated with SOCT is correlated with BCVA as well as with mf-ERG in patients with late-stage VKH disease.
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