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S. Kandula, S. Khan, K. Freund; Spectral-Domain Optical Coherence Tomography Characteristics of Multifocal Choroiditis and Punctate Inner Choroidopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5888.
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To describe characteristic spectral domain optical coherence tomography (SD-OCT) findings in patients with multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC).
Five eyes of three patients with MFC/PIC underwent SD-OCT at the time of diagnosis, and four eyes were examined with SD-OCT scans at frequent monthly visits thereafter. SD-OCT scans were evaluated both prior to and after the initiation of anti-inflammatory and/or anti-vascular endothelial growth factor (anti-VEGF) therapy.
Prior to treatment, eyes demonstrated drusen-like deposits between the retinal pigment epithelium (RPE) and Bruch’s membrane, presumed vitreous cells, and localized choroidal hyper-reflectivity below the areas of the sub-RPE drusen-like deposits. The sub-RPE deposits correlated to lesions found on color photographs. The areas of choroidal hyper-reflectivity below the sub-RPE deposits appeared to correlate with areas of overlying inner segment/outer segment (IS/OS) photoreceptor disorganization. Both the sub-RPE deposits and choroidal hyper-reflectivity improved following treatment with anti-inflammatory or anti-VEGF therapy.
MFC and PIC represent a disease spectrum that initially can be difficult to distinguish from myopic degeneration with choroidal neovascularization (CNV). MFC/PIC demonstrate characteristic SD-OCT findings that appear to improve with treatment. These SD-OCT findings may help in differentiating MFC/PIC from myopic CNV.
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