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T. Tachikawa, R. Ueno, T. Mita, T. Ishida, T. Noda, O. Katsumi; Axial Growth and Changes in Lenticular and Corneal Radius in Premature Infants During the First Year of Life. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5914.
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Premature children treated with laser have a higher prevalence of high myopia. We examined the variations in ocular biometric parameters and compared untreated and laser-treated eyes with retinopathy of prematurity (ROP).
The patients were divided into two primary groups by age and subgroups based on treatment: group 1: 92 eyes of 46 patients, gestational age at birth ≥22 weeks and ≤27 weeks (mean birth weight, 675.1±131.9 gm) (group 1A, 25 untreated eyes; group 1B, 67 laser-treated eyes); and group 2: 68 eyes of 34 patients, gestational age at birth ≥28 weeks and ≤34 weeks (mean birth weight, 1,215.2±357.1 gm) (group 2A, 54 untreated eyes; group 2B, 14 laser-treated eyes). The axial length (AL), corneal radius (CR), and lens thickness (LT) were measured in all infants using ultrasound A-scan biometry and keratometry. Changes in AL, CR, and LT were followed longitudinally during the first year of life (mean adjusted ages, 1-60 weeks).
Group 1 had a shorter AL (p<0.001, Mann-Whitney's U test) and decreased CR (increased corneal curvature) (p=0.006) than group 2. Group 1 also had increased LT compared with Group 2.(p=0.017). The AL and CR did not differ significantly between groups 1A and 1B (p=0.37 and p=0.43, respectively). The increased LT steadily decreased in group 1A but steadily increased in group 1B. The LT differed significantly between groups 1A and 1B (p=0.007) through most of the first year of life.
The results indicated that increased LT is a major contributor to myopia in laser-treated eyes with ROP during the first year of life.
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