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E. M. Stroh; Intravitreal Avastin Plus Laser Therapy in Aggressive Zone 1 Retinopathy of Prematurity - 30 Month Follow-Up. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5921.
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Prospective Case Series To Show The Benefit of Adjunctive Intravitreal Avastin with Laser Therapy for Posterior Aggressive Threshold Zone 1 Retinopathy of Prematurity (ROP) - 30 months follow-up.
13 eyes of 7 patients with Posterior Aggressive Zone 1 ROP were treated with intravitreal Avastin in addition to conventional laser treatment.
All 13 eyes had regression of plus disease and active ROP with combination therapy per this protocol. None progressed to retinal detachment, and one developed cataract that required surgery. Electroretinography showed changes consistent with extensive laser therapy and no progressive or additional retinal toxicity.
Larger studies should be performed to assess the benefit, optimum timing, and optimum dosage of supplemental Intravitreal Avastin with Laser Therapy for Posterior Aggressive Zone 1 ROP. Longer term follow-up needs to be performed to further determine the percentage of saved eyes that develop useful vision, as well as the incidence of strabismus, amblyopia, myopia, cataract, glaucoma, and late retinal detachment in these severe eyes that otherwise may have been lost to retinal detachment. Ongoing studies are in progress.
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