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D. H. Ghodasra, A. Thuangtong, K. Karp, G.-S. Ying, M. Mills, C. M. Wilson, A. R. Fielder, J. Ng, G. E. Quinn; Change in Retinal Vessel Width and Tortuosity in Eyes at Risk for Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5925.
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To describe the rate of change of retinal vessel width and tortuosityin eyes of babies with treatment-requiring, or type 1, retinopathyof prematurity (ROP) versus eyes of at risk babies without type1 ROP.
The posterior poles of at risk eyes were imaged with a 30-degreefundus camera. Retinal vessel width and tortuosity were measuredlongitudinally from digital images using computer-assisted imageanalysis software. The rate of change of vessel width or tortuositywas calculated using linear regression slope and compared betweentype 1 and non-type 1 ROP eyes by 2-sample t-test. Receiveroperating characteristic (ROC) analysis was performed to evaluatediscriminative power for type 1 ROP.
The mean rate of change of width for venules alone and 3 widestvessels were higher for type 1 ROP eyes than non-type 1 eyes(p<0.0001) (Table 1). The mean rate of change of tortuosityof arterioles alone and 3 most tortuous vessels were also higher(p<0.0001). These vessel parameters had moderate discriminativeability for type 1 ROP with area under the ROC curve (AUC) from0.79 to 0.90 (Table 2). A combination of venular width and arteriolartortuosity had the best discriminative ability with AUC of 0.96.
The rate of change of retinal vessel width and tortuosity ishigher in eyes that developed type 1 ROP than eyes that didnot. These measurement may be useful in the early identificationof eyes at risk for vision-threatening ROP.
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