April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Change in Retinal Vessel Width and Tortuosity in Eyes at Risk for Retinopathy of Prematurity
Author Affiliations & Notes
  • D. H. Ghodasra
    Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • A. Thuangtong
    Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • K. Karp
    Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • G.-S. Ying
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania
  • M. Mills
    Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • C. M. Wilson
    City University, London, United Kingdom
  • A. R. Fielder
    City University, London, United Kingdom
  • J. Ng
    Imperial College, London, United Kingdom
  • G. E. Quinn
    Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  D.H. Ghodasra, None; A. Thuangtong, None; K. Karp, None; G.-S. Ying, None; M. Mills, None; C.M. Wilson, None; A.R. Fielder, None; J. Ng, None; G.E. Quinn, None.
  • Footnotes
    Support  The Mabel E. Leslie Endowed Chair, The Doris Duke Charitable Foundation, The Paul & Evanina Bell Mackall Foundation Trust, Action Medical Research
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 5925. doi:
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      D. H. Ghodasra, A. Thuangtong, K. Karp, G.-S. Ying, M. Mills, C. M. Wilson, A. R. Fielder, J. Ng, G. E. Quinn; Change in Retinal Vessel Width and Tortuosity in Eyes at Risk for Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5925.

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Abstract
 
Purpose:
 

To describe the rate of change of retinal vessel width and tortuosityin eyes of babies with treatment-requiring, or type 1, retinopathyof prematurity (ROP) versus eyes of at risk babies without type1 ROP.

 
Methods:
 

The posterior poles of at risk eyes were imaged with a 30-degreefundus camera. Retinal vessel width and tortuosity were measuredlongitudinally from digital images using computer-assisted imageanalysis software. The rate of change of vessel width or tortuositywas calculated using linear regression slope and compared betweentype 1 and non-type 1 ROP eyes by 2-sample t-test. Receiveroperating characteristic (ROC) analysis was performed to evaluatediscriminative power for type 1 ROP.

 
Results:
 

The mean rate of change of width for venules alone and 3 widestvessels were higher for type 1 ROP eyes than non-type 1 eyes(p<0.0001) (Table 1). The mean rate of change of tortuosityof arterioles alone and 3 most tortuous vessels were also higher(p<0.0001). These vessel parameters had moderate discriminativeability for type 1 ROP with area under the ROC curve (AUC) from0.79 to 0.90 (Table 2). A combination of venular width and arteriolartortuosity had the best discriminative ability with AUC of 0.96.

 
Conclusions:
 

The rate of change of retinal vessel width and tortuosity ishigher in eyes that developed type 1 ROP than eyes that didnot. These measurement may be useful in the early identificationof eyes at risk for vision-threatening ROP.  

 

 
Keywords: retinopathy of prematurity • clinical (human) or epidemiologic studies: systems/equipment/techniques • visual development: infancy and childhood 
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